Gene expression is one of the most critical cellular processes. It is controlled by complex mechanisms at the genomic, epigenomic, transcriptomic, and proteomic levels. Any aberration in these mechanisms can lead to dysregulated gene expression. One recently discovered process that controls gene expression includes chemical modifications of RNA molecules by RNA-modifying proteins, a field known as epitranscriptomics. Epitranscriptomics can regulate mRNA splicing, nuclear export, stabilization, translation, or induce degradation of target RNA molecules. Dysregulation in RNA-modifying proteins has been found to contribute to many pathological conditions, such as cancer, diabetes, obesity, cardiovascular diseases, and neurological diseases, among others. This article reviews the role of epitranscriptomics in the pathogenesis and progression of renal cell carcinoma. It summarizes the molecular function of RNA-modifying proteins in the pathogenesis of renal cell carcinoma.

基因表达是最关键的细胞过程之一。它受基因组、表观基因组、转录组和蛋白质组水平的复杂机制控制。这些机制中的任何异常都可能导致基因表达失调。最近发现的一个控制基因表达的过程包括通过 RNA 修饰蛋白对 RNA 分子进行化学修饰，这一领域称为表观转录组学。表观转录组学可以调节 mRNA 剪接、核输出、稳定、翻译或诱导靶 RNA 分子的降解。人们发现 RNA 修饰蛋白的失调会导致许多病理状况，例如癌症、糖尿病、肥胖、心血管疾病和神经系统疾病等。本文综述了表观转录组学在肾细胞癌发病机制和进展中的作用。它总结了 RNA 修饰蛋白在肾细胞癌发病机制中的分子功能。