The individual woman’s risk of being diagnosed with breast cancer can now be estimated more precisely, and screening can be stratified accordingly. The risk assessment requires that women are willing to provide a blood test, additional personal information, to know their risk, and alter screening intervals. This study aimed to investigate Danish women’s attitudes towards risk-stratified breast cancer screening. An online, cross-sectional survey was conducted among Danish women aged 52–67 years. We used logistic regression analyses to assess how personal characteristics were associated with the women’s attitudes. 5,001 women completed the survey (response rate 44%) of which 74% approved of risk estimation to potentially alter their screening intervals. However, only 42% would accept an extended screening interval if found to have low breast cancer risk, while 89% would accept a reduced interval if at high risk. The main determinants of these attitudes were age, education, screening participation, history of breast cancer, perceived breast cancer risk and to some extent breast cancer worry. This study indicates that women are positive towards risk-stratified breast cancer screening. However, reservations and knowledge among subgroups of women must be carefully considered and addressed before wider implementation of risk-stratified breast cancer screening in a national program.

中文翻译：

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对风险分层乳腺癌筛查的态度：针对 5,001 名丹麦女性的人口调查

现在可以更准确地估计女性个体被诊断出患有乳腺癌的风险，并可以相应地对筛查进行分层。风险评估要求女性愿意提供血液检查、额外的个人信息，以了解她们的风险，并改变筛查间隔。本研究旨在调查丹麦女性对风险分层乳腺癌筛查的态度。对 52 至 67 岁丹麦女性进行了一项在线横断面调查。我们使用逻辑回归分析来评估个人特征与女性态度的关系。5,001 名女性完成了这项调查（回复率为 44%），其中 74% 的女性同意进行风险评估，以可能改变她们的筛查间隔。然而，如果发现乳腺癌风险较低，只有 42% 的人会接受延长筛查间隔，而如果乳腺癌风险较高，则 89% 的人会接受缩短筛查间隔。这些态度的主要决定因素是年龄、教育程度、筛查参与、乳腺癌病史、感知的乳腺癌风险以及某种程度上的乳腺癌担忧。这项研究表明，女性对风险分层乳腺癌筛查持积极态度。然而，在国家计划中更广泛地实施风险分层乳腺癌筛查之前，必须仔细考虑和解决女性亚群体的保留意见和知识。