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Risk of Major Congenital Malformations and Exposure to Antiseizure Medication Monotherapy.
JAMA Neurology ( IF 29.0 ) Pub Date : 2024-03-18 , DOI: 10.1001/jamaneurol.2024.0258 Dina Battino 1 , Torbjörn Tomson 2, 3 , Erminio Bonizzoni 4 , John Craig 5 , Emilio Perucca 6, 7 , Anne Sabers 8 , Sanjeev Thomas 9 , Silje Alvestad 10, 11 , Piero Perucca 12, 13, 14, 15, 16 , Frank Vajda 6 , Chiara Pantaleoni 17 , Claudia Ciaccio 17 , Silvia Kochen 17 , Frank Vajda 17 , Gerhard Luef 17 , Alejandro De Marinis 17 , Jana Zarubova 17 , Anne Sabers 17 , Reetta Kälviäinen 17 , Sofia Kasradze 17 , Bettina Schmitz 17 , Sanjeev V. Thomas 17 , Nasim Tabrizi 17 , Lilach Goldstein 17 , Barbara Mostacci 17 , Hideyuki Ohtani 17 , Gordana Kiteva-Trenchevska 17 , Eugène van Puijenbroek 17 , Silje Alvestad 17 , Maja Milovanović 17 , Vladimír Šafčák 17 , Meritxell Martinez Ferri 17 , Torbjörn Tomson 17 , Elisabeth Sellitto 17 , Hsiang-Yu Yu 17 , Stephanie Hödl 17 , Petr Marusic 17 , Renata Listonova 17 , Hana Krijtová 17 , David Franc 17 , Petr Busek 17 , Michaela Kajšová 17 , Noemi Andersen 17 , Birthe Pedersen 17 , Katarzyna Mieszczanek 17 , Katarzyna Cebula 17 , Stefan Juhl 17 , Birgitte Forsom Sondal 17 , Karen Nielsen 17 , Tatiana V. Danielsen 17 , Elsebeth Bruun Christiansen 17 , Jakob Christensen 17 , Ovidio Solano Cabrera 17 , Aleksei Rakitin 17 , Anne Kirss 17 , Anna M. Saukkonen 17 , Nino Gogatishvili 17 , Dieter Dennig 17 , Kerstin Erdmann 17 , Christian Dippon 17 , Bernhard Steinhoff 17 , Lisa M. Langenbruch 17 , Holger Lerche 17 , Anja Herzer 17 , Jan S. Gerdes 17 , Elisa K. El-Allawy-Zielke 17 , Hajo Hamer 17 , Malgorzata Kalita 17 , Martin Hirsch 17 , Stephan Arnold 17 , Hans-Beatus Straub 17 , Rebekka Lehmann 17 , Christiane Asenbauer 17 , Florian Losch 17 , Wenke Grönheit 17 , Matthias Lindenau 17 , Ramshekhar Menon 17 , Jafar Mehvari Habibabadi 17 , Maria P. Canevini 17 , Elena Zambrelli 17 , Katherine Turner 17 , Michela Cecconi 17 , Aldo Paggi 17 , Nicoletta Foschi 17 , Antonio Gambardella 17 , Simone Beretta 17 , Angela Giglio 17 , Gaia Fanella 17 , Lorenzo Ferri 17 , Francesca Bisulli 17 , Alessandra Pistelli 17 , Pietro Pignatta 17 , Marta Maschio 17 , Francesca Muzzi 17 , Maria S. Cotelli 17 , Etsuko Yamazaki 17 , Kiyohito Terada 17 , Yushi Inoue 17 , Masahiro Mizobuchi 17 , Katsuyuki Fukushima 17 , Masaaki Kato 17 , Takahiro Mitsueda 17 , Torleiv Svendsen 17 , Erik Taubøll 17 , Alma Sikiric 17 , Katrine Haggag 17 , Eline Dahl-Hansen 17 , Ineke Hogenesch 17 , Eylert Brodtkorb 17 , Isabel Pires 17 , Helena Rocha 17 , Marta Carvalho 17 , Ricardo Rego 17 , Carla Bentes 17 , Ana C. Gonçalves Franco 17 , Sara Parreira 17 , Halina Navumava 17 , Ksenija Gebauer Bukurov 17 , Juan L. Becerra Cuñat 17 , Clara Cabeza Alvarez 17 , Mercedes Garces Sanchez 17 , Gemma Sansa Fayos 17 , David Sopelana Garay 17 , Alvaro Sanchez Larsen 17 , Maria D. Castro Vilanova 17 , Lisa Gordon 17 , Peter Mattsson 17 , Eva Kumlien 17 , Maria Strandberg 17 , Avan S. Rashid 17 , Helena Gauffin 17 , Irene Hakansson 17 , Maria Bograkou 17 , Kristina Malmgren 17 , Dominique Flügel 17 , Stephan Rüegg 17 , Martin Kurthen 17 , Dilek Atakli 17 , Önder Kemal Soylu 17 , Janet E Graham 17 , Alison A Hitchcock 17 , Stefanie Gadeyne 17 , Katherine Moreno 17 , Hanna Jersing 17 , Karina Als 17 , Lone Olsen 17 , Julie Althoen Sønderup 17 , Pirjo Lavi 17 , Kirsten Krämer 17 , Siri Myklebust 17 , Mariann Høgli Grøtte 17 , Bibiane Moche Kamga 17 , Laura Gargantini 17 , Cristina Bonato 17 , Stefania Falchi 17 ,
JAMA Neurology ( IF 29.0 ) Pub Date : 2024-03-18 , DOI: 10.1001/jamaneurol.2024.0258 Dina Battino 1 , Torbjörn Tomson 2, 3 , Erminio Bonizzoni 4 , John Craig 5 , Emilio Perucca 6, 7 , Anne Sabers 8 , Sanjeev Thomas 9 , Silje Alvestad 10, 11 , Piero Perucca 12, 13, 14, 15, 16 , Frank Vajda 6 , Chiara Pantaleoni 17 , Claudia Ciaccio 17 , Silvia Kochen 17 , Frank Vajda 17 , Gerhard Luef 17 , Alejandro De Marinis 17 , Jana Zarubova 17 , Anne Sabers 17 , Reetta Kälviäinen 17 , Sofia Kasradze 17 , Bettina Schmitz 17 , Sanjeev V. Thomas 17 , Nasim Tabrizi 17 , Lilach Goldstein 17 , Barbara Mostacci 17 , Hideyuki Ohtani 17 , Gordana Kiteva-Trenchevska 17 , Eugène van Puijenbroek 17 , Silje Alvestad 17 , Maja Milovanović 17 , Vladimír Šafčák 17 , Meritxell Martinez Ferri 17 , Torbjörn Tomson 17 , Elisabeth Sellitto 17 , Hsiang-Yu Yu 17 , Stephanie Hödl 17 , Petr Marusic 17 , Renata Listonova 17 , Hana Krijtová 17 , David Franc 17 , Petr Busek 17 , Michaela Kajšová 17 , Noemi Andersen 17 , Birthe Pedersen 17 , Katarzyna Mieszczanek 17 , Katarzyna Cebula 17 , Stefan Juhl 17 , Birgitte Forsom Sondal 17 , Karen Nielsen 17 , Tatiana V. Danielsen 17 , Elsebeth Bruun Christiansen 17 , Jakob Christensen 17 , Ovidio Solano Cabrera 17 , Aleksei Rakitin 17 , Anne Kirss 17 , Anna M. Saukkonen 17 , Nino Gogatishvili 17 , Dieter Dennig 17 , Kerstin Erdmann 17 , Christian Dippon 17 , Bernhard Steinhoff 17 , Lisa M. Langenbruch 17 , Holger Lerche 17 , Anja Herzer 17 , Jan S. Gerdes 17 , Elisa K. El-Allawy-Zielke 17 , Hajo Hamer 17 , Malgorzata Kalita 17 , Martin Hirsch 17 , Stephan Arnold 17 , Hans-Beatus Straub 17 , Rebekka Lehmann 17 , Christiane Asenbauer 17 , Florian Losch 17 , Wenke Grönheit 17 , Matthias Lindenau 17 , Ramshekhar Menon 17 , Jafar Mehvari Habibabadi 17 , Maria P. Canevini 17 , Elena Zambrelli 17 , Katherine Turner 17 , Michela Cecconi 17 , Aldo Paggi 17 , Nicoletta Foschi 17 , Antonio Gambardella 17 , Simone Beretta 17 , Angela Giglio 17 , Gaia Fanella 17 , Lorenzo Ferri 17 , Francesca Bisulli 17 , Alessandra Pistelli 17 , Pietro Pignatta 17 , Marta Maschio 17 , Francesca Muzzi 17 , Maria S. Cotelli 17 , Etsuko Yamazaki 17 , Kiyohito Terada 17 , Yushi Inoue 17 , Masahiro Mizobuchi 17 , Katsuyuki Fukushima 17 , Masaaki Kato 17 , Takahiro Mitsueda 17 , Torleiv Svendsen 17 , Erik Taubøll 17 , Alma Sikiric 17 , Katrine Haggag 17 , Eline Dahl-Hansen 17 , Ineke Hogenesch 17 , Eylert Brodtkorb 17 , Isabel Pires 17 , Helena Rocha 17 , Marta Carvalho 17 , Ricardo Rego 17 , Carla Bentes 17 , Ana C. Gonçalves Franco 17 , Sara Parreira 17 , Halina Navumava 17 , Ksenija Gebauer Bukurov 17 , Juan L. Becerra Cuñat 17 , Clara Cabeza Alvarez 17 , Mercedes Garces Sanchez 17 , Gemma Sansa Fayos 17 , David Sopelana Garay 17 , Alvaro Sanchez Larsen 17 , Maria D. Castro Vilanova 17 , Lisa Gordon 17 , Peter Mattsson 17 , Eva Kumlien 17 , Maria Strandberg 17 , Avan S. Rashid 17 , Helena Gauffin 17 , Irene Hakansson 17 , Maria Bograkou 17 , Kristina Malmgren 17 , Dominique Flügel 17 , Stephan Rüegg 17 , Martin Kurthen 17 , Dilek Atakli 17 , Önder Kemal Soylu 17 , Janet E Graham 17 , Alison A Hitchcock 17 , Stefanie Gadeyne 17 , Katherine Moreno 17 , Hanna Jersing 17 , Karina Als 17 , Lone Olsen 17 , Julie Althoen Sønderup 17 , Pirjo Lavi 17 , Kirsten Krämer 17 , Siri Myklebust 17 , Mariann Høgli Grøtte 17 , Bibiane Moche Kamga 17 , Laura Gargantini 17 , Cristina Bonato 17 , Stefania Falchi 17 ,
Affiliation
Women with epilepsy (WWE) require treatment with antiseizure medications (ASMs) during pregnancy, which may be associated with an increased risk of major congenital malformations (MCMs) in their offspring.
中文翻译：
严重先天畸形和接受抗癫痫药物单一疗法的风险。
患有癫痫 (WWE) 的女性在怀孕期间需要接受抗癫痫药物 (ASM) 治疗，这可能会增加其后代患严重先天性畸形 (MCM) 的风险。
更新日期：2024-03-18
中文翻译：
严重先天畸形和接受抗癫痫药物单一疗法的风险。
患有癫痫 (WWE) 的女性在怀孕期间需要接受抗癫痫药物 (ASM) 治疗，这可能会增加其后代患严重先天性畸形 (MCM) 的风险。
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