Turmeric is widely used worldwide, and there are many examples of its use in treating hepatobiliary diseases. The gut–liver axis is a bidirectional relationship between gut microorganisms and the liver that is closely related to the pathogenesis of hepatobiliary diseases. This review systematically summarizes the components of turmeric. It links the studies on turmeric affecting gut microorganisms to its effects on liver and biliary diseases to explain the potential mechanism of turmeric’s regulation of the gut–liver axis. Besides, ethnopharmacology, phytochemicals, and clinical adverse events associated with turmeric have been researched. Furthermore, turmeric is a safe agent with good clinical efficacy and without apparent toxicity at a certain amount. By summarizing the influence of turmeric on the liver by regulating the gut–liver axis, especially the gut microbiota, it provides a preclinical basis for using turmeric as a safe and effective therapeutic agent for the prevention and treatment of hepatobiliary diseases based on the gut–liver axis. However, more efforts should be made to exploit its clinical application further.

姜黄在世界范围内广泛使用，并且有许多用于治疗肝胆疾病的例子。肠肝轴是肠道微生物与肝脏之间的双向关系，与肝胆疾病的发病机制密切相关。这篇综述系统地总结了姜黄的成分。它将姜黄影响肠道微生物的研究与其对肝脏和胆道疾病的影响联系起来，以解释姜黄调节肠-肝轴的潜在机制。此外，还对与姜黄相关的民族药理学、植物化学物质和临床不良事件进行了研究。此外，姜黄是一种安全的药物，临床疗效良好，在一定剂量下无明显毒性。通过总结姜黄通过调节肠-肝轴，特别是肠道菌群对肝脏的影响，为姜黄作为安全有效的治疗剂预防和治疗基于肠-肝轴的肝胆疾病提供了临床前基础。肝轴。然而，仍需付出更多努力来进一步开发其临床应用。