Plasma NEDD9 is increased following SARS-CoV-2 infection and associates with indices of pulmonary vascular dysfunction,Pulmonary Circulation

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Plasma NEDD9 is increased following SARS-CoV-2 infection and associates with indices of pulmonary vascular dysfunction
Pulmonary Circulation ( IF 2.6 ) Pub Date : 2024-03-18 , DOI: 10.1002/pul2.12356
George A. Alba _{1,

2} , Iris Y. Zhou _{1,

3,

4} , Molly Mascia _{1,

2} , Michael Magaletta ₃ , Jehan W. Alladina _{1,

2} , Francesca L. Giacona ₂ , Leo C. Ginns _{1,

2} , Peter Caravan _{1,

3,

4} , Bradley A. Maron _{5,

6} , Sydney B. Montesi _{1,

2,

4}

Affiliation

Compared to healthy volunteers, participants with post-acute sequelae of SARS-CoV-2 infection (PASC) demonstrated increased plasma levels of the prothrombotic protein NEDD9, which associated inversely with indices of pulmonary vascular function. This suggests persistent pulmonary vascular dysfunction may play a role in the pathobiology of PASC.

中文翻译：

SARS-CoV-2 感染后血浆 NEDD9 升高，并与肺血管功能障碍指数相关

与健康志愿者相比，患有 SARS-CoV-2 感染（PASC）急性后遗症的参与者表现出血浆中血栓前蛋白 NEDD9 水平升高，这与肺血管功能指数呈负相关。这表明持续性肺血管功能障碍可能在 PASC 的病理学中发挥作用。

更新日期：2024-03-19

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