Over recent years, the investigation of transposable elements (TEs) has granted researchers a deeper comprehension of their characteristics and functions, particularly regarding their significance in the mechanisms contributing to cancer development. This manuscript focuses on prostate carcinoma cell lines and offers a comprehensive review intended to scrutinize the associations and interactions between TEs and genes, as well as their response to treatment using various chemical drugs, emphasizing their involvement in cancer progression. We assembled a compendium of articles retrieved from the PubMed database to construct networks demonstrating correlations with genes and pharmaceuticals. In doing so, we linked the transposition of certain TE types to the expression of specific transcripts directly implicated in carcinogenesis. Additionally, we underline that treatment employing different drugs revealed unique patterns of TE reactivation. Our hypothesis gathers the current understanding and guides research toward evidence‐based investigations, emphasizing the association between antiviral drugs, chemotherapy, and the reduced expression of TEs in patients affected by prostate cancer.

中文翻译：

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恶性前列腺癌细胞中受药物影响的转座元件调节的最新技术

近年来，对转座因子（TE）的研究使研究人员对其特征和功能有了更深入的理解，特别是它们在促进癌症发展的机制中的重要性。本手稿重点关注前列腺癌细胞系，并提供了全面的综述，旨在审查 TE 和基因之间的关联和相互作用，以及它们对各种化学药物治疗的反应，强调它们在癌症进展中的参与。我们整理了从 PubMed 数据库检索到的文章概要，以构建展示基因和药物相关性的网络。在此过程中，我们将某些 TE 类型的转座与直接涉及致癌作用的特定转录本的表达联系起来。此外，我们强调使用不同药物的治疗揭示了 TE 再激活的独特模式。我们的假设收集了当前的理解并指导研究转向循证调查，强调抗病毒药物、化疗和前列腺癌患者中 TE 表达减少之间的关联。