NUP155 is reported to be correlated with tumor development. However, the role of NUP155 in tumor physiology and the tumor immune microenvironment (TIME) has not been previously examined. This study comprehensively investigated the expression, immunological function, and prognostic significance of NUP155 in different cancer types. Bioinformatics analysis revealed that NUP155 was upregulated in 26 types of cancer. Additionally, NUP155 upregulation was strongly correlated with advanced pathological or clinical stages and poor prognosis in several cancers. Furthermore, NUP155 was significantly and positively correlated with DNA methylation, tumor mutational burden, microsatellite instability, and stemness score in most cancers. Additionally, NUP155 was also found to be involved in TIME and closely associated with tumor infiltrating immune cells and immunoregulation-related genes. Functional enrichment analysis revealed a strong correlation between NUP155 and immunomodulatory pathways, especially antigen processing and presentation. The role of NUP155 in breast cancer has not been examined. This study, for the first time, demonstrated that NUP155 was upregulated in breast invasive carcinoma (BRCA) cells and revealed its oncogenic role in BRCA using molecular biology experiments. Thus, our study highlights the potential value of NUP155 as a biomarker in the assessment of prognostic prediction, tumor microenvironment and immunotherapeutic response in pan-cancer.

中文翻译：

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NUP155 的泛癌分析及其在乳腺癌细胞增殖、迁移和凋亡中的作用验证

据报道，NUP155 与肿瘤发展相关。然而，NUP155在肿瘤生理学和肿瘤免疫微环境（TIME）中的作用此前尚未被研究过。本研究全面研究了NUP155在不同癌症类型中的表达、免疫功能和预后意义。生物信息学分析显示，NUP155 在 26 种癌症中表达上调。此外，NUP155 上调与多种癌症的晚期病理或临床分期以及不良预后密切相关。此外，在大多数癌症中，NUP155 与 DNA 甲基化、肿瘤突变负荷、微卫星不稳定性和干性评分显着正相关。此外，NUP155还被发现参与TIME并与肿瘤浸润免疫细胞和免疫调节相关基因密切相关。功能富集分析揭示了 NUP155 与免疫调节途径之间存在很强的相关性，尤其是抗原加工和呈递。NUP155 在乳腺癌中的作用尚未得到研究。这项研究首次证明NUP155在乳腺浸润性癌（BRCA）细胞中表达上调，并通过分子生物学实验揭示了其在BRCA中的致癌作用。因此，我们的研究强调了 NUP155 作为生物标志物在评估泛癌预后、肿瘤微环境和免疫治疗反应方面的潜在价值。