In this investigation, the cytotoxic activity of phenazine compounds from different bacterial strains of Pseudomonas chlororaphis subsp. aurantiaca against the HeLa cervical adenocarcinoma cell line was studied. The cytotoxic concentrations of phenazines against HeLa cells were 300 μg/mL. After incubation with phenazines, cytological preparations of HeLa cells showing the presence of apoptotic bodies were obtained. The effect of phenazines on HeLa cells led to a change in the expression of their ABC transporter genes (abcc1 and abcg2) and tp53. The activity of tp53 increased almost 13-fold, while the expression of the abcc1 and abcg2 genes decreased. The activation of tp53 is one of the probable causes of apoptotic death of HeLa cells in the presence of phenazine compounds from the bacterium P. chlororaphis subsp. aurantiaca.

在这项研究中，来自绿针假单胞菌亚种不同菌株的吩嗪化合物的细胞毒活性。研究了aurantiaca对抗 HeLa 宫颈腺癌细胞系的作用。吩嗪对 HeLa 细胞的细胞毒性浓度为 300 μg/mL。与吩嗪一起孵育后，获得了显示凋亡小体存在的 HeLa 细胞的细胞学制剂。吩嗪对 HeLa 细胞的作用导致其 ABC 转运蛋白基因（abcc1和abcg2）和tp53的表达发生变化。tp53的活性增加了近 13 倍，而abcc1和abcg2基因的表达下降。tp53的激活是 HeLa 细胞在来自细菌P. loraphis subsp. 的吩嗪化合物存在下凋亡的可能原因之一。橙花。