BackgroundUp to two thirds of patients presenting for abdominal cancer surgery are malnourished pre‐operatively. Perioperative nutritional supplementation has been proposed to improve surgical outcomes, though its effect on quality of life (QoL) is not yet understood.MethodsA randomized controlled feasibility trial for perioperative nutrition among patients undergoing major abdominal cancer surgery was conducted. Participants in the intervention group received supplements for 30 days before surgery. Participants completed two QoL questionnaires (EORTC‐QLQ‐C‐30 and FACT‐G) at baseline, then 4 and 12 weeks postoperatively. Participants were compared between and within groups at baseline, Weeks 4, and 12 using t tests. Minimal clinically important differences (MCIDs) were considered as a 10‐point worsening from baseline.ResultsSixty‐six participants were available for analysis in this study, including 33 in the intervention and 30 in the control arms. Baseline demographics were balanced between groups except for different rates of pancreas cancer (36% intervention vs. 9% control) and colorectal cancer (19% intervention vs. 34% control). At baseline, participants in the intervention group had lower overall QoL (59% vs. 77%, p = 0.01), role functioning (72% vs 88%, p = 0.045), and cognitive functioning (79% vs 90%, p = 0.047). Following surgery, role and physical functioning worsened in the control group, without significant differences between groups. Role functioning was persistently worsened at 12 weeks in the control group. The rates of MCIDs were similar between both intervention and control groups.DiscussionPerioperative nutrition was associated with preservation of QoL in the postoperative period following major abdominal cancer surgery compared to placebo.SummaryAmong patients undergoing surgery for cancer, the majority present at high risk for malnutrition. In this placebo‐controlled randomized trial among patients undergoing major abdominal surgery for cancer, preoperative nutrition supplementation was associated with the preservation of QoL in the postoperative period.

中文翻译：

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接受胃肠道癌症手术的患者围手术期营养补充剂优​​化后的生活质量：一项随机、安慰剂对照的可行性临床试验

背景多达三分之二接受腹部癌症手术的患者术前营养不良。围手术期营养补充已被提出可以改善手术结果，但其对生活质量（QoL）的影响尚不清楚。方法对接受腹部癌症大手术的患者进行围手术期营养的随机对照可行性试验。干预组的参与者在手术前 30 天接受补充剂。参与者在基线、术后 4 周和 12 周完成了两份生活质量调查问卷（EORTC-QLQ-C-30 和 FACT-G）。使用以下方法在基线、第 4 周和第 12 周对参与者进行组间和组内比较：t测试。最小临床重要差异 (MCID) 被认为是与基线相比恶化 10 分。结果 66 名参与者可用于本研究的分析，其中 33 名参加干预组，30 名参加对照组。除了胰腺癌（36% 干预组 vs. 9% 对照）和结直肠癌（19% 干预组 vs. 34% 对照组）的不同发病率外，各组之间的基线人口统计数据是平衡的。在基线时，干预组参与者的总体生活质量较低（59% vs. 77%，p= 0.01），角色功能（72% vs 88%，p= 0.045）和认知功能（79% vs 90%，p= 0.047）。手术后，对照组的角色和身体功能恶化，但组间没有显着差异。对照组的角色功能在 12 周时持续恶化。干预组和对照组之间的 MCID 发生率相似。讨论与安慰剂相比，围手术期营养与腹部癌症手术后术后时期生活质量的保持相关。总结在接受癌症手术的患者中，大多数存在营养不良的高风险。在这项针对癌症腹部大手术患者的安慰剂对照随机试验中，术前营养补充与术后生活质量的保持相关。