Colorectal cancer (CRC) is recognized as one of the most common gastrointestinal malignancies across the globe. Despite significant progress in designing novel treatments for CRC, there is a pressing need for more effective therapeutic approaches. Unfortunately, many patients undergoing chemotherapy develop drug resistance, posing a significant challenge for cancer treatment. Non‐coding RNAs (ncRNAs) have been found to play crucial roles in CRC development and its response to chemotherapy. However, there are still gaps in our understanding of interactions among various ncRNAs, such as long non‐coding RNAs (lncRNAs), circular RNAs (circRNAs) and microRNAs (miRNAs). These ncRNAs can act as either oncogenes or tumour suppressors, affecting numerous biological functions in different cancers including CRC. A class of ncRNA molecules known as competitive endogenous RNAs (ceRNAs) has emerged as a key player in various cellular processes. These molecules form networks through lncRNA/miRNA/mRNA and circRNA/miRNA/mRNA interactions. In CRC, dysregulation of ceRNA networks has been observed across various cellular processes, including proliferation, apoptosis and angiogenesis. These dysregulations are believed to play a significant role in the progression of CRC and, in certain instances, may contribute to the development of chemoresistance. Enriching our knowledge of these dysregulations holds promise for advancing the field of diagnostic and therapeutic modalities for CRC. In this review, we discuss lncRNA‐ and circRNA‐associated ceRNA networks implicated in the emergence and advancement of drug resistance in colorectal carcinogenesis.

中文翻译：

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竞争性内源性RNA网络：解码长链非编码RNA和环状RNA在结直肠癌化疗耐药中的作用

结直肠癌（CRC）被认为是全球最常见的胃肠道恶性肿瘤之一。尽管在设计新的结直肠癌治疗方法方面取得了重大进展，但仍迫切需要更有效的治疗方法。不幸的是，许多接受化疗的患者产生耐药性，给癌症治疗带来了重大挑战。研究发现非编码 RNA (ncRNA) 在 CRC 的发展及其对化疗的反应中发挥着至关重要的作用。然而，我们对各种 ncRNA 之间相互作用的理解仍然存在差距，例如长非编码 RNA (lncRNA)、环状 RNA (circRNA) 和 microRNA (miRNA)。这些 ncRNA 可以作为癌基因或肿瘤抑制基因，影响包括结直肠癌在内的不同癌症的许多生物学功能。一类被称为竞争性内源性 RNA (ceRNA) 的 ncRNA 分子已成为各种细胞过程中的关键参与者。这些分子通过 lncRNA/miRNA/mRNA 和 circRNA/miRNA/mRNA 相互作用形成网络。在结直肠癌中，在各种细胞过程中都观察到了 ceRNA 网络的失调，包括增殖、凋亡和血管生成。这些失调被认为在结直肠癌的进展中发挥着重要作用，并且在某些情况下可能导致化学耐药性的发展。丰富我们对这些失调的了解有望推动结直肠癌诊断和治疗方式领域的发展。在这篇综述中，我们讨论了与结直肠癌发生中耐药性的出现和进展有关的 lncRNA 和 circRNA 相关 ceRNA 网络。