It was designed to identify the symptom clusters and sentinel symptoms among patients with breast cancer receiving chemotherapy at the community level, and to explore core and bridge symptoms at the global level. A cross-sectional survey was conducted using the MD Anderson Symptom Inventory. Patients with breast cancer receiving chemotherapy, recruited from the “Be Resilient to Breast Cancer” project between January 2023 and December 2023, were included in the study. Symptom clusters and their sentinel symptoms were identified using exploratory factor analysis and Apriori algorithm. Core and bridge symptoms were identified using network analysis. A total of 468 patients with breast cancer participated in the current study. At the community level, three symptom clusters and their corresponding sentinel symptoms were identified: a gastrointestinal symptom cluster (with nausea as the sentinel symptom), a psycho-sleep-related symptom cluster (with distress as the sentinel symptom), and a neurocognition symptom cluster (with dry mouth as the sentinel symptom). At the global level, fatigue emerged as the core symptom, while disturbed sleep and lack of appetite as bridge symptoms. Addressing nausea, distress, and dry mouth are imperative for alleviating specific symptom clusters at the community level. Furthermore, targeting fatigue, disturbed sleep, and lack of appetite are crucial to break the interactions among diverse symptoms at the global level.

中文翻译：

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接受化疗的乳腺癌患者的前哨症状和网络症状

它旨在识别社区层面接受化疗的乳腺癌患者的症状群和前哨症状，并在全球层面探索核心症状和过渡症状。使用 MD 安德森症状清单进行了一项横断面调查。该研究纳入了2023年1月至2023年12月期间从“Be Resilient to Breast Cancer”项目招募的接受化疗的乳腺癌患者。使用探索性因素分析和 Apriori 算法来识别症状群及其前哨症状。使用网络分析来识别核心和桥梁症状。共有 468 名乳腺癌患者参与了本研究。在社区层面，确定了三个症状群及其相应的哨兵症状：胃肠道症状群（以恶心为哨兵症状）、心理睡眠相关症状群（以痛苦为哨兵症状）和神经认知症状集群（以口干为哨兵症状）。在全球范围内，疲劳成为核心症状，而睡眠障碍和食欲不振则是过渡症状。解决恶心、痛苦和口干对于缓解社区层面的特定症状群至关重要。此外，针对疲劳、睡眠障碍和食欲不振对于打破全球范围内不同症状之间的相互作用至关重要。