The precision control of monodisperse nanomaterials with spatially distinct functionalities and properties is of particular interest in materials science. Creating biocompatible/biodegradable nanoparticles that can be colloidally stable in aqueous solution further paves the way to a broad range of bio-related applications. In present work, we demonstrate the precise fabrication of aliphatic polycarbonate based one-dimensional (1D) cylinders and 2D platelet micelles using living crystallization-driven self-assembly (CDSA) by seeded growth method. By synthesizing aliphatic polycarbonate core-forming block copolymers with different corona-to-core ratios, excellent control over dimensions of 1D cylinders and 2D platelets with good uniformity is achieved through effectively epitaxial growth in ethanol based on the mass ratios of unimer-to-seed. Meanwhile, segmented nanoparticles with spatially-defined chemistries can further be prepared by sequential seeded growth approach. Moreover, these 1D/2D nanostructures are colloidally stable in water, and further show excellently biocompatible property towards L929 cells. These promising properties of polycarbonate-based micelles enable to a wide application as cargo vehicles in bio-related fields.

中文翻译：

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聚（碳酸六亚甲基酯）嵌段共聚物的一维/二维组装的精确控制

具有空间上不同的功能和特性的单分散纳米材料的精确控制在材料科学中特别令人感兴趣。创造在水溶液中胶体稳定的生物相容性/可生物降解的纳米颗粒进一步为广泛的生物相关应用铺平了道路。在目前的工作中，我们展示了通过种子生长方法使用活结晶驱动自组装（CDSA）精确制造基于脂肪族聚碳酸酯的一维（1D）圆柱体和2D血小板胶束。通过合成具有不同冠核比的脂肪族聚碳酸酯成核嵌段共聚物，通过基于单聚体与种子的质量比在乙醇中有效外延生长，实现了对一维圆柱体和具有良好均匀性的二维片晶的尺寸的良好控制。同时，具有空间限定化学性质的分段纳米粒子可以通过顺序种子生长方法进一步制备。此外，这些1D/2D纳米结构在水中是胶体稳定的，并且进一步对L929细胞表现出优异的生物相容性。聚碳酸酯基胶束的这些有前途的特性使其能够作为生物相关领域的货运车辆得到广泛应用。