Methicillin-resistant (MRSA) and other drug-resistant bacteria have become more common in recent years, which has made it extremely difficult to treat and heal many different kinds of wounds and caused enormous financial losses. Because of its unique “Trojan horse” function, Ga has been recognized as a new possible candidate for inhibiting and eradicating drug-resistant bacteria. Furthermore, natural polysaccharide materials with outstanding biological characteristics, such as insect chitosan (CS) and pullulan (PUL), have attracted significant interest. In this study, we used quaternized-catechol chitosan (QDCS-PA), methacrylate-dialdehyde pullulan (DPUL-GMA), and gallium ion (Ga) to create a multi-crosslinked photo-enhanced hydrogel (Q-D/Ga/UV) with antimicrobial, hemostatic, self-healing, and injectable properties for promoting MRSA-infected wound healing. In vitro, the Q-D/Ga/UV hydrogels demonstrated good mechanical properties, antioxidant capabilities, biocompatibility, hemostatic properties, and antibacterial activity. The addition of gallium ions enhanced the hydrogels' mechanical properties, hemostatic capabilities, antibacterial activity, and ability to induce wound healing. Q-D/Ga/UV hydrogel significantly promoted wound contraction, collagen deposition, and angiogenesis while also suppressing inflammation in a whole-skin wound model of MRSA-infected rats. In conclusion, Q-D/Ga/UV hydrogels demonstrate significant promise for healing wounds infected with drug-resistant bacteria.

中文翻译：

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具有多种生物活性的昆虫壳聚糖/支链淀粉/镓光交联水凝胶促进MRSA感染的伤口愈合

近年来，耐甲氧西林（MRSA）和其他耐药细菌变得越来越普遍，这使得许多不同类型的伤口的治疗和愈合变得极其困难，并造成了巨大的经济损失。由于其独特的“特洛伊木马”功能，Ga被认为是抑制和根除耐药细菌的新的可能候选者。此外，具有突出生物学特性的天然多糖材料，如昆虫壳聚糖（CS）和支链淀粉（PUL）也引起了人们的极大兴趣。在这项研究中，我们使用季铵化儿茶酚壳聚糖（QDCS-PA）、甲基丙烯酸二醛普鲁兰多糖（DPUL-GMA）和镓离子（Ga）创建了一种多重交联的光增强水凝胶（QD/Ga/UV）抗菌、止血、自愈和可注射特性，可促进 MRSA 感染的伤口愈合。在体外，QD/Ga/UV水凝胶表现出良好的机械性能、抗氧化能力、生物相容性、止血性能和抗菌活性。添加镓离子增强了水凝胶的机械性能、止血能力、抗菌活性和诱导伤口愈合的能力。 QD/Ga/UV 水凝胶显着促进伤口收缩、胶原沉积和血管生成，同时还抑制 MRSA 感染大鼠全皮伤口模型的炎症。总之，QD/Ga/UV 水凝胶在治愈耐药细菌感染的伤口方面表现出巨大的前景。