Breast cancer remains one of the most intractable diseases, especially the malignant form of metastasis, with which the cancer cells are hard to track and eliminate. Herein, the common known carbohydrate polymer chitosan (CS) was innovatively used as a shelter for the potent tumor-killing agent. The designed nanoparticles (NPs) not only enhance the solubility of hydrophobic paclitaxel (PTX), but also provide a “hide” effect for cytotoxic PTX in physiological condition. Moreover, coupled with the photothermal (PTT) properties of MoS, results in a potent chemo/PTT platform. The MoS@PTX-CS-K237 NPs have a uniform size (135 ± 17 nm), potent photothermal properties (η = 31.5 %), and environment-responsive (low pH, hypoxia) and near infrared (NIR) laser irradiation-triggered PTX release. Through a series of and experiments, the MoS@PTX-CS-K237 showed high affinity and specificity for breast cancer cells, impressive tumor killing capacity, as well as the effective inhibitory effect of metastasis. Benefit from the unique optical properties of MoS, this multifunctional nanomedicine also exhibited favorable thermal/PA/CT multimodality imaging effect on tumor-bearing mice. The system developed in this work represents the advanced design concept of hierarchical stimulus responsive drug release, and merits further investigation as a potential nanotheranostic platform for clinical translation.

中文翻译：

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一种壳聚糖伪装的纳米药物，通过分层刺激触发释放药物，用于乳腺癌多模态成像引导化疗

乳腺癌仍然是最棘手的疾病之一，尤其是恶性转移，癌细胞很难追踪和消除。在此，常见的碳水化合物聚合物壳聚糖（CS）被创新地用作强效肿瘤杀灭剂的庇护所。设计的纳米颗粒（NPs）不仅增强了疏水性紫杉醇（PTX）的溶解度，而且在生理条件下为细胞毒性PTX提供了“隐藏”作用。此外，与MoS2的光热（PTT）特性相结合，形成了一个有效的化疗/PTT平台。 MoS@PTX-CS-K237 NP 具有均匀的尺寸 (135 ± 17 nm)、有效的光热特性 (η = 31.5 %)、环境响应性（低 pH、缺氧）和近红外 (NIR) 激光照射触发PTX 释放。通过一系列实验，MoS@PTX-CS-K237对乳腺癌细胞表现出高亲和力和特异性，具有令人印象深刻的肿瘤杀伤能力，以及有效的抑制转移作用。受益于MoS独特的光学特性，这种多功能纳米药物还对荷瘤小鼠表现出良好的热/PA/CT多模态成像效果。这项工作中开发的系统代表了分层刺激响应药物释放的先进设计理念，值得进一步研究作为临床转化的潜在纳米治疗平台。