The development of exopolysaccharide-based polymers is gaining increasing attention in various industrial biotechnology fields for materials such as thickeners, texture modifiers, anti-freeze agents, antioxidants, and antibacterial agents. High-viscosity carboxyethyl-succinoglycan (CE-SG) was directly synthesized from succinoglycan (SG) isolated from Rm 1021, and its structural, rheological, and physiological properties were investigated. The viscosity of CE-SG gradually increased in proportion to the degree of carboxyethylation substitution. In particular, when the molar ratio of SG and 3-chloropropionic acid was 1:100, the viscosity was significantly improved by 21.18 times at a shear rate of 10 s. Increased carboxyethylation of SG also improved the thermal stability of CE-SG. Furthermore, the CE-SG solution showed 90.18 and 91.78 % antibacterial effects against and and effective antioxidant activity against DPPH and hydroxyl radicals. In particular, CE-SG hydrogels coordinated with Fe ions, which improved both viscosity and rheological properties, while also exhibiting reduction-responsive drug release through 1,4-dithiothreitol. The results of this study suggest that SG derivatives, such as CE-SG, can be used as functional biomaterials in various fields such as food, cosmetics, and pharmaceutical industries.

中文翻译：

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使用基于羧乙基琥珀聚糖的还原响应水凝胶进行药物输送，具有高度改善的流变学、抗菌和抗氧化特性

基于胞外多糖的聚合物的开发在增稠剂、质地改良剂、防冻剂、抗氧化剂和抗菌剂等材料的各种工业生物技术领域中受到越来越多的关注。从 Rm 1021 中分离的琥珀聚糖 (SG) 直接合成高粘度羧乙基琥珀聚糖 (CE-SG)，并研究了其结构、流变学和生理学特性。 CE-SG的粘度随着羧乙基化取代度的增加而逐渐增加。特别是当SG与3-氯丙酸的摩尔比为1:100时，在10 s的剪切速率下，粘度显着提高了21.18倍。 SG 羧乙基化的增加也提高了 CE-SG 的热稳定性。此外，CE-SG溶液对DPPH和羟基自由基表现出90.18%和91.78%的抗菌作用和有效的抗氧化活性。特别是，CE-SG 水凝胶与 Fe 离子配位，改善了粘度和流变特性，同时还通过 1,4-二硫苏糖醇表现出还原响应性药物释放。这项研究的结果表明，SG衍生物，如CE-SG，可以作为功能性生物材料应用于食品、化妆品和制药行业等各个领域。