当前位置：
X-MOL 学术
›
Cancer Lett.
›
论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Biodistribution and therapeutic efficacy of a gold nanoparticle-based targeted drug delivery system against pancreatic cancer
Cancer Letters ( IF 9.7 ) Pub Date : 2024-03-15 , DOI: 10.1016/j.canlet.2024.216810 Chandra Kumar Elechalawar , Suresh Kumar Gulla , Ram Vinod Roy , Nicolas Means , Yushan Zhang , Sima Asifa , David J. Robertson , Chao Xu , Resham Bhattacharya , Priyabrata Mukherjee
Cancer Letters ( IF 9.7 ) Pub Date : 2024-03-15 , DOI: 10.1016/j.canlet.2024.216810 Chandra Kumar Elechalawar , Suresh Kumar Gulla , Ram Vinod Roy , Nicolas Means , Yushan Zhang , Sima Asifa , David J. Robertson , Chao Xu , Resham Bhattacharya , Priyabrata Mukherjee
Pancreatic cancer is characterized by desmoplasia; crosstalk between pancreatic cancer cells (PCCs) and pancreatic stellate cells (PSCs) leads to the deposition of extracellular matrix proteins in the tumor environment resulting in poor vascularity. Targeting either PCCs or PSCs individually has produced mixed results, and there is currently no effective strategy to target both cell types simultaneously. Previously, we demonstrated, through cell culture experiments, that a specific gold nanoparticle-based nanoformulation containing the anti-EGFR antibody cetuximab (C225) as a targeting agent and gemcitabine as a chemotherapeutic agent effectively targets both PCCs and PSCs simultaneously. Herein, we extend our studies to test the ability of these tested nano formulations to inhibit tumor growth in an orthotopic co-implantation model of pancreatic cancer . Orthotopic tumors were established by co-implantation of equal numbers of PCCs and PSCs in the mouse pancreas. Among the various formulations tested, 5 nm gold nanoparticles coated with gemcitabine, cetuximab and poly-ethylene glycol (PEG) of molecular weight 1000 Da, which we named ACGP441000, demonstrated optimal efficacy in inhibiting tumor growth. The current study reveals an opportunity to target PCCs and PSCs simultaneously, by exploiting their overexpression of EGFR as a target, in order to inhibit pancreatic cancer growth.
更新日期：2024-03-15
京公网安备 11010802027423号