() is associated with the development of oral cancer. Here, we report the altered tumor microenvironment in oral tumor-bearing mice caused by infection. Single-cell RNA sequencing showed that . infection influenced the tumor microenvironment significantly. Specifically, infection reduced the CD8 T cells but increased the IL-17A CD4 T cells and IL-17A γδ T cells in oral tumor. The neutralization of IL-17A or TCR γ/δ alleviated the tumor progression caused by infection. Additionally, infection promoted the infiltration of myeloid-derived suppressor cells (MDSCs) into tumor, especially polymorphonuclear (PMN)-MDSCs, which infiltration was reduced after the neutralization of CCL2. Thus, our findings reveal the myeloid cells-T lymphocytes axis in oral tumor microenvironment with infection, which helps to understand the mechanisms for promoting oral cancer from the perspective of immune microenvironment.

中文翻译：

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口腔荷瘤小鼠肿瘤微环境中白色念珠菌-髓系细胞-T淋巴细胞轴

()与口腔癌的发生有关。在这里，我们报告了感染引起的口腔肿瘤小鼠肿瘤微环境的改变。单细胞 RNA 测序表明。感染显着影响肿瘤微环境。具体而言，口腔肿瘤中感染减少了 CD8 T 细胞，但增加了 IL-17A CD4 T 细胞和 IL-17A γδ T 细胞。 IL-17A或TCR γ/δ的中和减轻了感染引起的肿瘤进展。此外，感染促进了骨髓源性抑制细胞（MDSC）向肿瘤的浸润，尤其是多形核（PMN）-MDSC，中和CCL2后其浸润减少。因此，我们的研究结果揭示了感染时口腔肿瘤微环境中的骨髓细胞-T淋巴细胞轴，这有助于从免疫微环境的角度理解促进口腔癌的机制。