Herein, we introduce a facile and efficient method for the synthesis of imidazo [1,2-a]pyridines containing CF-substituted tertiary alcohol moieties using trifluoropyruvates as synthons under metal-free reaction conditions. The reaction promoted by the HFIP proceeds well at room temperature, displaying good to satisfactory yields and high functional group tolerance. Some advantages of the protocol are mild reaction conditions, simple operation and ready scalability.

中文翻译：

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HFIP促进室温下含CF3取代叔醇的咪唑并[1,2-a]吡啶的合成

在此，我们介绍了一种在无金属反应条件下使用三氟丙酮酸盐作为合成子合成含有CF-取代叔醇部分的咪唑并[1,2-a]吡啶的简便有效的方法。 HFIP 促进的反应在室温下进行良好，显示出良好至令人满意的产率和高官能团耐受性。该方案的优点是反应条件温和、操作简单、可扩展性好。