Infectious diseases are a cause of major concern in this twenty-first century. There have been reports of various outbreaks like severe acute respiratory syndrome (SARS) in 2003, swine flu in 2009, Zika virus disease in 2015, and Middle East Respiratory Syndrome (MERS) in 2012, since the start of this millennium. In addition to these outbreaks, the latest infectious disease to result in an outbreak is the SARS-CoV-2 infection. A viral infection recognized as a respiratory illness at the time of emergence, SARS-CoV-2 has wreaked havoc worldwide because of its long-lasting implications like heart failure, sepsis, organ failure, etc., and its significant impact on the global economy. Besides the acute illness, it also leads to symptoms months later which is called long COVID or post-COVID-19 condition. Due to its ever-increasing prevalence, it has been a significant challenge to treat the affected individuals and manage the complications as well. Myocarditis, a long-term complication of coronavirus disease 2019 (COVID-19) is an inflammatory condition involving the myocardium of the heart, which could even be fatal in the long term in cases of progression to ventricular dysfunction and heart failure. Thus, it is imperative to diagnose early and treat this condition in the affected individuals. At present, there are numerous studies which are in progress, investigating patients with COVID-19-related myocarditis and the treatment strategies. This review focuses primarily on myocarditis, a life-threatening complication of COVID-19 illness, and endeavors to elucidate the pathogenesis, biomarkers, and management of long COVID myocarditis along with pipeline drugs in detail.

中文翻译：

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了解长期新冠肺炎心肌炎：全面回顾

传染病是二十一世纪备受关注的一个问题。进入新世纪以来，已有各种疫情爆发的报道，例如2003年的严重急性呼吸综合症（SARS）、2009年的猪流感、2015年的寨卡病毒病和2012年的中东呼吸综合症（MERS）。除了这些疫情之外，导致疫情爆发的最新传染病是 SARS-CoV-2 感染。 SARS-CoV-2 是一种在出现时被认为是呼吸道疾病的病毒感染，由于其造成的心力衰竭、败血症、器官衰竭等长期影响，以及对全球经济的重大影响，在世界范围内造成了严重破坏。 。除了急性疾病外，它还会导致几个月后出现症状，称为长期 COVID 或 COVID-19 后病症。由于其患病率不断增加，治疗受影响的个体并管理并发症一直是一项重大挑战。心肌炎是 2019 年冠状病毒病 (COVID-19) 的一种长期并发症，是一种累及心脏心肌的炎症性疾病，从长远来看，如果进展为心室功能障碍和心力衰竭，甚至可能致命。因此，必须尽早诊断并治疗受影响个体的这种情况。目前，有大量研究正在进行中，调查 COVID-19 相关心肌炎患者及其治疗策略。本综述主要关注心肌炎（一种危及生命的 COVID-19 疾病并发症），并努力详细阐明长期 COVID 心肌炎的发病机制、生物标志物和治疗以及正在研发的药物。