Hirschsprung-associated enterocolitis (HAEC) is the most common cause of morbidity and mortality in patients with Hirschsprung disease (HD). There is a correlation between social determinants of health (SDOH) and outcomes in children with HD. The Child Opportunity Index (COI) is a publicly available dataset that stratifies patients by address into levels of opportunity. We aimed to understand if a relationship exists between COI and HAEC. A single-institution, IRB-approved, retrospective cohort study was performed of children with HD. Census tract information was used to obtain COI scores, which were stratified into categories (very low, low, medium, high, very high). Subgroups with and without history of HAEC were compared. The cohort had 100 patients, of which 93 had a COI score. There were 27 patients (29.0%) with HAEC. There were no differences in demographics or clinical factors, including length of aganglionic colon, operative approach, and age at pull-through. As child opportunity score increased from very low to very high, there was a statistically significant decrease in the incidence of HAEC ( = 0.04). We demonstrate a significant association between increasing opportunity and decreasing incidence of HAEC. This suggests an opportunity for targeted intervention in populations with low opportunity. III. IRB14-00232.

中文翻译：

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先天性巨结肠相关小肠结肠炎的发病率随着儿童机会指数的增加而降低

先天性巨结肠相关小肠结肠炎 (HAEC) 是先天性巨结肠 (HD) 患者发病和死亡的最常见原因。健康社会决定因素 (SDOH) 与 HD 儿童的结局之间存在相关性。儿童机会指数 (COI) 是一个公开可用的数据集，可按地址对患者进行机会级别的分层。我们的目的是了解 COI 和 HAEC 之间是否存在关系。对患有 HD 的儿童进行了一项经 IRB 批准的单一机构回顾性队列研究。人口普查区信息用于获取 COI 分数，该分数分为几类（非常低、低、中、高、非常高）。对有和没有 HAEC 病史的亚组进行了比较。该队列有 100 名患者，其中 93 名有 COI 评分。有27名患者（29.0%）患有HAEC。人口统计学或临床因素（包括无神经节结肠的长度、手术方法和拔出时的年龄）没有差异。随着儿童机会分数从非常低增加到非常高，HAEC 的发生率在统计上显着下降 ( = 0.04)。我们证明了机会增加和 HAEC 发生率降低之间存在显着关联。这表明有机会对机会较少的人群进行有针对性的干预。三． IRB14-00232。