Obsessive-compulsive symptoms (OCS) are relatively common during adolescence although most individuals do not meet diagnostic criteria for obsessive-compulsive disorder (OCD). Nonetheless, OCS during adolescence are associated with comorbid psychopathologies and behavioral problems. Heightened levels of environmental stress and greater functional connectivity between the somatomotor network and putamen have been previously associated with elevated OCS in OCD patients relative to healthy controls. However, the interaction of these factors within the same sample of individuals has been understudied. This study examined somatomotor-putamen resting state connectivity, stress, and their interaction on OCS in adolescents from 9–12 years of age. Participants ( = 6386) were drawn from the ABCD Study 4.0 release. Multilevel modeling was used to account for nesting in the data and to assess changes in OCS in this age range. Stress moderated the association between somatomotor-putamen connectivity and OCS (β = 0.35, = 0.13, = 0.006). Participants who reported more stress than their average and had greater somatomotor-left putamen connectivity reported OCS, whereas participants who reported less stress than their average and had greater somatomotor-left putamen connectivity reported OCS. These data suggest that stress differentially affects the direction of association between somatomotor-putamen connectivity and OCS. Individual differences in the experience or perception of stress may contribute to more OCS in adolescents with greater somatomotor-putamen connectivity.

中文翻译：

---

青春期早期，躯体运动-壳核静息状态连接性与强迫症状之间的关联随着压力的变化而变化：来自 ABCD 研究的数据

强迫症状（OCS）在青春期相对常见，尽管大多数人不符合强迫症（OCD）的诊断标准。尽管如此，青春期的 OCS 与共存的精神病理学和行为问题有关。相对于健康对照组，环境压力水平的升高以及躯体运动网络和壳核之间功能连接的增强与强迫症患者的 OCS 升高有关。然而，这些因素在同一个体样本中的相互作用尚未得到充分研究。这项研究检查了 9-12 岁青少年的体运动-壳核静息状态连接、压力及其对 OCS 的相互作用。参与者 (= 6386) 选自 ABCD 研究 4.0 版本。使用多级建模来解释数据中的嵌套并评估该年龄范围内 OCS 的变化。压力调节躯体运动壳核连接与 OCS 之间的关联（β = 0.35，= 0.13，= 0.006）。报告压力高于平均水平且躯体运动左壳核连接性更强的参与者报告了 OCS，而报告压力低于平均水平且躯体运动左壳核连接性更强的参与者报告了 OCS。这些数据表明，压力对躯体运动壳核连接与 OCS 之间的关联方向有不同的影响。压力体验或感知的个体差异可能会导致躯体运动-壳核连通性更强的青少年出现更多的 OCS。