Vinpocetine attenuates methotrexate-induced hippocampal intoxication via Keap-1/Nrf2, NF-κB/AP-1, and apoptotic pathways in rats,Drug and Chemical Toxicology

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Vinpocetine attenuates methotrexate-induced hippocampal intoxication via Keap-1/Nrf2, NF-κB/AP-1, and apoptotic pathways in rats
Drug and Chemical Toxicology ( IF 2.6 ) Pub Date : 2024-03-20 , DOI: 10.1080/01480545.2024.2329155
Badrah Alghamdi _{1,

2} , Emad H. M. Hassanein ₃ , Saif A. Alharthy _{4,

5} , Reem M. Farsi ₆ , Steve Harakeh _{7,

8}

Affiliation

Methotrexate (MTX) is an anti-folate chemotherapeutic commonly used to treat cancer and autoimmune diseases. Despite its widespread clinical use, MTX has been linked to serious neurotoxicity side e...

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