Tumor microenvironment severely restricts the delivery of chemotherapy drugs. The microenvironment responsive nanoparticles often have complex designs with hampered clinical translatability. Here, we show a kind of ionic liquids (ILs) with soybean lecithin (SL) as cation, folic acid (FA) as anion, in particular, it could formulate nanoliposome by film evaporation method to deliver cis-Diamineplatinum (II) dichloride (cisplatin, Cis) and doxorubicin hydrochloride (DOX). These special ILs liposome could target tumor cells via folate receptor-mediated endocytosis by enhancing the cellular uptake, and significantly improve the deep permeability by actively infiltrating throughout the tumor tissue owing to the special noncovalent bond between SL–FA ILs with cell membrane. Moreover, ILs liposomes improve delivery efficiency of Cis and DOX and enhance the combined chemotherapeutic effect. The simple preparation process of the ILs nanoliposome should facilitate the clinical transformation of nanodrugs.

肿瘤微环境严重限制化疗药物的输送。微环境响应纳米粒子通常具有复杂的设计，从而阻碍了临床可转化性。在这里，我们展示了一种以大豆卵磷脂（SL）为阳离子、叶酸（FA）为阴离子的离子液体（ILs），特别是它可以通过薄膜蒸发方法配制纳米脂质体来递送顺式二氯化二胺铂（II）（顺铂（Cis）和盐酸阿霉素（DOX）。这些特殊的ILs脂质体可以通过叶酸受体介导的内吞作用增强细胞摄取来靶向肿瘤细胞，并由于SL-FA ILs与细胞膜之间的特殊非共价键而主动渗透到整个肿瘤组织中，从而显着提高深层渗透性。此外，ILs脂质体提高了Cis和DOX的递送效率，增强了联合化疗效果。 ILs纳米脂质体制备工艺简单，有望促进纳米药物的临床转化。