Magnetic field-assisted drug delivery is a fascinating strategy to transport chemotherapeutic drugs. Ferrite nanoparticles (NPs) of the form MFe₂O₄ are a good choice for utilization as magnetic nanocarriers. Although many ferrite NPs have been tested for their function as nanocarriers, their nonspecific toxicity must be minimized. In this work, calcium–nickel ferrite nanoparticles (CNF MNPs) coated with dextran–$\beta$-cyclodextrin and dextran–$\beta$-cyclodextrin–dextran polymers are reported. The synthesized NPs are characterized using XRD, TEM, EDX and XPS. The magnetic properties are investigated by vibrating sample magnetometry. The 20 nm-sized CNF MNPs fall in the size range suitable for cancer drug transport. The magnetic nanocarriers containing the polymers are superparamagnetic. The camptothecin (CPT) loading efficiency is observed as 88%. The in vitro CPT release profiles are sustained, displaying a continuous release for a period of above 45 h. The cytotoxicity studies on A549 cell lines reveal that the CPT-loaded CNF MNPs are active against them and can be used as an anticancer drug carrier.

磁场辅助药物递送是一种令人着迷的化疗药物运输策略。 MFe ₂ O ₄形式的铁氧体纳米粒子（NP）是用作磁性纳米载体的良好选择。尽管许多铁氧体纳米颗粒的纳米载体功能已经过测试，但必须尽量减少其非特异性毒性。在这项工作中，钙镍铁氧体纳米颗粒（CNF MNP）涂有葡聚糖–$\beta$-环糊精和葡聚糖–$\beta$据报道，β-环糊精-葡聚糖聚合物。使用 XRD、TEM、EDX 和 XPS 对合成的 NP 进行表征。通过振动样品磁力测定法研究磁性。 20 nm 大小的 CNF MNP 属于适合癌症药物运输的尺寸范围。含有聚合物的磁性纳米载体是超顺磁性的。观察到喜树碱 (CPT) 负载效率为 88%。体外CPT 释放曲线是持续的，显示持续释放时间超过 45 小时。对 A549 细胞系的细胞毒性研究表明，负载 CPT 的 CNF MNP 对它们具有活性，可用作抗癌药物载体。