Thunder God Vine has multiple effects such as anti-inflammatory, anti-tumor, and anti-fertility. One of its main active ingredients, triptriolide, can exert anti-tumor effects by targeting transcription factors, kinases, or inhibiting the ubiquitin/proteasome pathway to inhibit cell proliferation and promote tumor cell apoptosis. However, its high toxicity and poor water solubility limit its application. This study aims to develop a novel photoelectrochemical (PEC) sensor based on MoS₂/Bi₂MoO₆ nanohybrids for the rapid and accurate detection of triptriolide. The PEC sensor is a fundamental tool for extracting and identifying valuable bioactive compounds from this plant. Under optimal conditions, 0.01–10$$ng$$mL${}^{-1}$ of triptriolide could be identified, with the detection limit being as low as 0.005$$ng$$mL${}^{-1}$. With advantages like rapid response, high sensitivity and preferable stability, the developed sensor is suitable for real-time monitoring of triptriolide levels in actual samples.

雷神藤具有抗炎、抗肿瘤、抗生育等多种功效。其主要活性成分之一雷公藤内酯可通过靶向转录因子、激酶或抑制泛素/蛋白酶体途径抑制细胞增殖、促进肿瘤细胞凋亡而发挥抗肿瘤作用。但其毒性大、水溶性差限制了其应用。本研究旨在开发一种基于MoS ₂ /Bi ₂ MoO ₆纳米杂化物的新型光电化学（PEC）传感器，用于快速准确地检测雷公藤内酯。 PEC 传感器是从该植物中提取和识别有价值的生物活性化合物的基本工具。最佳条件下，0.01–10$$吴$$毫升${}^{-1}$可检出雷公藤内酯，检出限低至0.005$$吴$$毫升${}^{-1}$。该传感器具有响应速度快、灵敏度高、稳定性好等优点，适合实际样品中雷公藤内酯含量的实时监测。