With the continuous development of antibacterial nanotechnology, nanoparticle-mediated photothermal therapy (PTT) could treat dental implant bacterial infections. Here, a carbon quantum dots (CQDs) loading penicillin (CQDs@penicillin) was constructed as an innovative nanoplatforms to confer promising PTT and delivery of antibiotics. In this nanosystem, CQDs with distinct antibacterial application performance were utilized as an ideal nanocarrier for drug loading, evoking photothermal effects to generate heat under near-infrared (NIR) irradiation. The delivery of penicillin could induce damage to the bacterial cell wall and play a bactericidal effect during the reproduction period of bacterial cells. The antibacterial effects in vitro implied that CQDs@penicillin could significantly kill bacterial cells without severe toxicity. This study proposes a feasible therapeutic strategy for the delivery of antibiotics to dental implant bacterial infections and simultaneously the PTT effect.

随着抗菌纳米技术的不断发展，纳米粒子介导的光热疗法（PTT）可以治疗牙种植体细菌感染。在这里，负载青霉素的碳量子点（CQD）（CQDs@青霉素）被构建为创新的纳米平台，以赋予有前途的 PTT 和抗生素的递送。在该纳米系统中，具有独特抗菌应用性能的CQD被用作载药的理想纳米载体，在近红外（NIR）照射下引起光热效应产生热量。青霉素的输送可以引起细菌细胞壁的损伤，在细菌细胞的繁殖期间发挥杀菌作用。体外抗菌作用 表明CQDs@青霉素可以显着杀死细菌细胞，且没有严重毒性。这项研究提出了一种可行的治疗策略，用于治疗牙种植体细菌感染并同时发挥 PTT 作用。