Background

Offspring born to mothers with pre-eclampsia (Pre-E) suffer higher risks of adult cardiovascular diseases, suggesting that exposure to an antiangiogenic environment in-utero has a lasting impact on the development of endothelial function. The goal of this study is to test the hypothesis that in-utero exposure to Pre-E results in alterations of angiogenic factors/cytokines that negatively impact vascular development during infancy.

Methods

Infants born from mothers with and without Pre-E were recruited and followed up at 6 months. Plasma cytokines, blood pressure, microvessel density, and vascular reactivity were assessed.

Results

6-month-old infants born to mothers with Pre-E had unchanged blood pressure (p = 0.86) and microvessel density (p = 0.57). Vascular reactivity was decreased in infants born to mothers with Pre-E compared to infants born to healthy mothers (p = 0.0345). Interleukin 8 (IL-8) (p = 0.03) and Angiopoeitin-2 (Ang-2) (p = 0.04) were increased in infants born to mothers with Pre-E. We observed that higher IL-8 was associated with lower vascular reactivity (rho = −0.14, p < 0.0001).

Conclusion

At 6 months of age, infants born to mothers with Pre-E had impaired vascular reactivity and higher IL-8 and Ang-2, but similar blood pressure and microvessel density compared to infants born to non-Pre-E mothers.

Impact Statement

• Changes in cord blood antiangiogenic factors are documented in infants of mothers with pre-eclampsia and may contribute to offspring risks of adult cardiovascular disease. How these factors evolve during early infancy and their correlation with offspring vascular development have not been studied.

• This study found that 6-month-old infants born to mothers with pre-eclampsia had decreased vascular reactivity, which was correlated with higher IL-8.

• These findings underscore the lasting impact of maternal pre-eclampsia on offspring vascular development and highlight the need for long-term follow-up in children born to mothers with pre-eclampsia.

中文翻译：

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先兆子痫母亲所生的 6 个月大婴儿的血管反应性降低与 IL-8 升高相关

背景

患有先兆子痫（Pre-E）的母亲所生的后代患成人心血管疾病的风险较高，这表明子宫内暴露于抗血管生成环境对内皮功能的发育具有持久影响。本研究的目的是检验以下假设：子宫内暴露于 Pre-E 会导致血管生成因子/细胞因子发生变化，从而对婴儿期血管发育产生负面影响。

方法

招募患有和不患有 Pre-E 的母亲所生的婴儿，并在 6 个月时进行随访。评估血浆细胞因子、血压、微血管密度和血管反应性。

结果

患有 Pre-E 的母亲所生的 6 个月大婴儿的血压 ( p  = 0.86) 和微血管密度 ( p  = 0.57) 没有变化。与健康母亲所生的婴儿相比，患有 Pre-E 的母亲所生的婴儿的血管反应性降低 ( p  = 0.0345)。患有 Pre-E 的母亲所生的婴儿中白细胞介素 8 (IL-8) ( p  = 0.03) 和血管生成素-2 (Ang-2) ( p  = 0.04) 升高。我们观察到较高的 IL-8 与较低的血管反应性相关（rho = -0.14，p  < 0.0001）。

结论

在 6 个月大时，Pre-E 母亲所生的婴儿与非 Pre-E 母亲所生的婴儿相比，血管反应性受损，IL-8 和 Ang-2 较高，但血压和微血管密度相似。

影响报告

• 患有先兆子痫的母亲的婴儿中记录了脐带血抗血管生成因子的变化，这可能会增加后代患成人心血管疾病的风险。这些因素在婴儿早期如何演变及其与后代血管发育的相关性尚未研究。

• 这项研究发现，患有先兆子痫的母亲所生的 6 个月大婴儿的血管反应性降低，这与较高的 IL-8 相关。

• 这些发现强调了母亲先兆子痫对后代血管发育的持久影响，并强调需要对先兆子痫母亲所生的孩子进行长期随访。