Breast cancer is the most common female malignancy worldwide and a major cause of morbidity and mortality. Exercise during adjuvant treatment improves function and relieves symptoms in breast cancer survivors. However, it is unclear if an unsupervised exercise programme may be as effective as a supervised multimodal group. We investigated the feasibility and efficacy of a centre-based multidimensional rehabilitation (MDR) programme for breast cancer survivors undergoing adjuvant treatment and compared it to an unsupervised home-based exercise (HE) programme. Participants were self-allocated to either MDR or HE group. MDR participants underwent 24 supervised exercise classes and 10 education classes over 12 weeks. HE participants were instructed on a home exercise regime. Outcome measures, including the 6-min walk test (6MWT) and Frenchay Activities Index (FAI), FACT-Cognitive Function scale, and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30, were conducted at baseline (W0), post-intervention (W12) and 6-months post-intervention (M6). Variance between time points and the 2 groups were analysed using a linear mixed model (unstructured covariance matrix) and adjusted with Bonferroni. Twenty-five participants attended at least half of the MDR interventions, while 21 completed the HE interventions. The former showed significant improvement in 6MWT, from 406.88 m (W0) to 443.34 m (W12) to 452.81 m (M6), while the improvement in the HE group was not significant (407.67 m (W0) to 433.14 m (W12) to 430.96 m (M6)). Both groups showed a significant improvement in FAI, with earlier significant improvement noted at W12 in the MDR group (22.71 (W0) to 27.65 (W12) to 28.81 (M6)) compared to the HE group (23.16 (W0) to 26.47 (W12) to 29.85 (M6)). Dropout rate was 16% in the MDR group and 34% in HE group. Overall satisfaction with the MDR programme was high. Both MDR and HE programmes were feasible. MDR was superior in improving endurance and earlier return to instrumental activities for those who completed at least half of the sessions. Future studies could explore use of technology to improve adherence to exercise. The study was registered with ClinicalTrial.gov on 01/04/2022 with the registration number NCT05306808.

中文翻译：

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比较癌症辅助治疗期间多维乳腺癌康复计划与家庭锻炼计划的疗效

乳腺癌是全世界最常见的女性恶性肿瘤，也是发病和死亡的主要原因。辅助治疗期间的锻炼可以改善乳腺癌幸存者的功能并缓解症状。然而，尚不清楚无人监督的锻炼计划是否与监督的多模式团体一样有效。我们调查了针对接受辅助治疗的乳腺癌幸存者的中心多维康复 (MDR) 计划的可行性和有效性，并将其与无监督的家庭运动 (HE) 计划进行了比较。参与者自行分配到 MDR 组或 HE 组。 MDR 参与者在 12 周内接受了 24 门有监督的运动课程和 10 门教育课程。 HE 参与者接受了家庭锻炼制度的指导。结果测量在基线（W0 ）、干预后（W12）和干预后 6 个月（M6）。使用线性混合模型（非结构化协方差矩阵）分析时间点和 2 组之间的方差，并使用 Bonferroni 进行调整。 25 名参与者参加了至少一半的 MDR 干预措施，21 名参与者完成了 HE 干预措施。前者在6MWT中表现出显着的改善，从406.88 m（W0）到443.34 m（W12）再到452.81 m（M6），而HE组的改善并不显着（407.67 m（W0）到433.14 m（W12）到452.81 m（M6））。 430.96 m（M6））。两组的 FAI 均显示出显着改善，与 HE 组 (23.16 (W0) 至 26.47 (W12) 相比，MDR 组在第 12 周时出现了显着改善（22.71 (W0) 至 27.65 (W12) 至 28.81 (M6)）。 ) 至 29.85 (M6))。 MDR 组的脱落率为 16%，HE 组的脱落率为 34%。对 MDR 计划的总体满意度很高。 MDR 和 HE 计划都是可行的。对于完成至少一半课程的人来说，MDR 在提高耐力和尽早恢复工具活动方面表现出色。未来的研究可以探索利用技术来提高锻炼的坚持性。该研究于 2022 年 1 月 4 日在 ClinicalTrial.gov 注册，注册号为 NCT05306808。