Hemorrhoids and psychiatric disorders exhibit high prevalence rates and a tendency for relapse in epidemiological studies. Despite this, limited research has explored their correlation, and these studies are often subject to reverse causality and residual confounding. We conducted a Mendelian randomization (MR) analysis to comprehensively investigate the association between several mental illnesses and hemorrhoidal disease. Genetic associations for four psychiatric disorders and hemorrhoidal disease were obtained from large consortia, the FinnGen study, and the UK Biobank. Genetic variants associated with depression, bipolar disorder, anxiety disorders, schizophrenia, and hemorrhoidal disease at the genome-wide significance level were selected as instrumental variables. Screening for potential confounders in genetic instrumental variables using PhenoScanner V2. Bidirectional MR estimates were employed to assess the effects of four psychiatric disorders on hemorrhoidal disease. Our analysis revealed a significant association between genetically predicted depression and the risk of hemorrhoidal disease (IVW, OR=1.20,95% CI=1.09 to 1.33, P <0.001). We found no evidence of associations between bipolar disorder, anxiety disorders, schizophrenia, and hemorrhoidal disease. Inverse MR analysis provided evidence for a significant association between genetically predicted hemorrhoidal disease and depression (IVW, OR=1.07,95% CI=1.04 to 1.11, P <0.001). This study offers MR evidence supporting a bidirectional causal relationship between depression and hemorrhoidal disease.

中文翻译：

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痔疮疾病及其与抑郁症、躁郁症、焦虑症和精神分裂症的遗传关联：双向孟德尔随机化研究

在流行病学研究中，痔疮和精神疾病表现出较高的患病率和复发趋势。尽管如此，有限的研究探索了它们的相关性，并且这些研究经常受到反向因果关系和残留混杂的影响。我们进行了孟德尔随机化（MR）分析，以全面调查几种精神疾病与痔疮疾病之间的关联。四种精神疾病和痔疮疾病的遗传关联是从大型联盟、FinnGen 研究和英国生物银行获得的。选择在全基因组显着性水平上与抑郁症、双相情感障碍、焦虑症、精神分裂症和痔疮疾病相关的遗传变异作为工具变量。使用 PhenoScanner V2 筛选遗传工具变量中的潜在混杂因素。采用双向 MR 估计来评估四种精神疾病对痔疮疾病的影响。我们的分析显示，基因预测的抑郁症与痔疮疾病风险之间存在显着关联（IVW，OR=1.20，95% CI=1.09 至 1.33，P <0.001）。我们没有发现双相情感障碍、焦虑症、精神分裂症和痔疮疾病之间存在关联的证据。反向MR分析为遗传预测的痔疮疾病与抑郁症之间的显着关联提供了证据（IVW，OR=1.07，95% CI=1.04至1.11，P<0.001）。这项研究提供了 MR 证据，支持抑郁症和痔疮疾病之间存在双向因果关系。