: Atherosclerosis is the pathophysiological basis for major diseases, such as coronary heart disease, cerebral stroke, and peripheral arterial disease, which have become epidemic in modern Western society. Atherosclerosis has a complex nature that involves mutually related immune and metabolic mechanisms. Many cells of the vascular wall and peripheral bloodstream, including endothelial cells, monocytes and macrophages, platelets, and others, are involved in the development and progression of atherosclerosis. These cells perform a number of innate immune functions, disorders of which are associated with atherosclerosis. Furthermore, lipids are not only a morphological substrate but also important participants in the development of atherosclerosis. They are involved in the development and resolution of inflammation and mediate vascular cell function.

中文翻译：

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脂质和脂质介质参与炎症和动脉粥样硬化形成

：动脉粥样硬化是现代西方社会流行的冠心病、脑中风、外周动脉疾病等重大疾病的病理生理基础。动脉粥样硬化具有复杂的性质，涉及相互相关的免疫和代谢机制。血管壁和外周血流的许多细胞，包括内皮细胞、单核细胞和巨噬细胞、血小板等，参与动脉粥样硬化的发生和进展。这些细胞执行许多先天免疫功能，其疾病与动脉粥样硬化有关。此外，脂质不仅是形态底物，而且是动脉粥样硬化发展的重要参与者。它们参与炎症的发生和消退并介导血管细胞功能。