Abstract

AgeMeta is a database that provides systemic and quantitative description of mammalian aging at the level of gene expression. It encompasses transcriptomic changes with age across various tissues of humans, mice, and rats, based on a comprehensive meta-analysis of 122 publicly available gene expression datasets from 26 studies. AgeMeta provides an intuitive visual interface for quantification of aging-associated transcriptomics at the level of individual genes and functional groups of genes, allowing easy comparison among various species and tissues. Additionally, all the data in the database can be downloaded and analyzed independently. Overall, this work contributes to the understanding of the complex network of biological processes underlying mammalian aging and supports future advancements in this field. AgeMeta is freely available at: https://age-meta.com/.

Graphic abstract

摘要

AgeMeta 是一个在基因表达水平上系统、定量描述哺乳动物衰老的数据库。它基于对 26 项研究的 122 个公开基因表达数据集的综合荟萃分析，涵盖了人类、小鼠和大鼠各种组织随年龄增长的转录组变化。 AgeMeta 提供了直观的可视化界面，用于在单个基因和基因功能组水平上量化与衰老相关的转录组学，从而可以轻松比较不同物种和组织。此外，数据库中的所有数据都可以独立下载和分析。总体而言，这项工作有助于理解哺乳动物衰老背后的复杂生物过程网络，并支持该领域的未来进展。 AgeMeta 可免费获取：https://age-meta.com/。

图文摘要