Abstract

For most of their lifespan, the probability of death for many animal species increases with age. Gompertz law states that this increase is exponential. In this work, we have compared previously published data on the survival kinetics of different lines of progeric mice. Visual analysis showed that in six lines of these rapidly aging mutants, the probability of death did not strictly depend on age. In contrast, ten lines of progeric mice have survival curves similar to those of the control animals, that is, in agreement with Gompertz law, similar to the shape of an exponential curve upside down. Interestingly, these ten mutations cause completely different cell malfunctions. We speculate that what these mutations have in common is a reduction in the lifespan of cells and/or an acceleration of the transition to the state of cell senescence. Thus, our analysis, similar to the conclusions of many previously published works, indicates that the aging of an organism is a consequence of the aging of individual cells.

中文翻译：

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不同品系早衰小鼠的两种生存曲线

摘要

对于许多动物物种来说，在其一生的大部分时间里，死亡的可能性随着年龄的增长而增加。冈珀兹定律指出，这种增长是指数级的。在这项工作中，我们比较了之前发表的不同品系早衰小鼠的生存动力学数据。视觉分析表明，在这些快速衰老突变体的六个品系中，死亡概率并不严格取决于年龄。相比之下，十系早衰小鼠的生存曲线与对照动物相似，即符合冈珀茨定律，类似于倒置的指数曲线形状。有趣的是，这十种突变会导致完全不同的细胞功能障碍。我们推测这些突变的共同点是细胞寿命缩短和/或加速向细胞衰老状态的转变。因此，我们的分析与许多先前发表的作品的结论类似，表明生物体的衰老是单个细胞衰老的结果。