Preclinical pharmacokinetic investigation of the bioavailability and skin distribution of HY-072808 ointment, a novel drug candidate for the treatment of atopic dermatitis, in minipigs by a newly LC-MS/MS method,Xenobiotica

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Preclinical pharmacokinetic investigation of the bioavailability and skin distribution of HY-072808 ointment, a novel drug candidate for the treatment of atopic dermatitis, in minipigs by a newly LC-MS/MS method
Xenobiotica ( IF 1.8 ) Pub Date : 2024-04-02 , DOI: 10.1080/00498254.2024.2333007
Li Shao ₁ , Jiajia Mo ₁ , Qinlong Xu ₁ , Guangwei He ₁ , Chunyu Xing ₂ , Zhaoxing Chu ₁

Affiliation

HY-072808 is a novel phosphodiesterase 4 inhibitor clinically used for topical atopic dermatitis treatment. Cytochrome P450 enzymes are involved in transforming it into major metabolite ZZ-24. An e...

中文翻译：

采用新的 LC-MS/MS 方法对 HY-072808 软膏（治疗特应性皮炎的新候选药物）在小型猪中的生物利用度和皮肤分布进行临床前药代动力学研究

HY-072808是一种新型磷酸二酯酶4抑制剂，临床用于局部特应性皮炎治疗。细胞色素 P450 酶参与将其转化为主要代谢物 ZZ-24。一个电...

更新日期：2024-04-02

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