Targeting two radiation-induced immunosuppressive pathways to improve the efficacy of normofractionated radiation therapy in a preclinical colorectal cancer model,International Journal of Radiation Biology

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Targeting two radiation-induced immunosuppressive pathways to improve the efficacy of normofractionated radiation therapy in a preclinical colorectal cancer model
International Journal of Radiation Biology ( IF 2.6 ) Pub Date : 2024-03-20 , DOI: 10.1080/09553002.2024.2331115
Jihane Boustani _{1,

2} , Benoit Lecoester ₂ , Jérémy Baude ₃ , Charlène Latour _{4,

5} , Emeric Limagne _{4,

5} , Riad Ladjohoulou _{4,

5} , Véronique Morgand _{4,

5} , Lisa Froidurot _{4,

5} , François Ghiringhelli _{4,

5} , Gilles Truc _{3,

5} , Olivier Adotévi _{2,

6} , Céline Mirjolet _{4,

5}

Affiliation

We have previously demonstrated in a murine colorectal cancer model that normofractionated RT (normoRT: 18 × 2 Gy) induced MDSC infiltration and PD-L1 expression, while hypofractionated RT (hypoRT:...

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