ObjectiveLow-frequency oscillations (LFOs) observed in the periphery may reflect physiological processes. The aim of this study was to investigate these processes’ effects on LFOs and the differences between healthy subjects and those with peripheral arteriosclerosis disease (PAD).Methods14 PAD patients and 25 healthy controls were studied in resting (RS) and passive leg raising (PLR) states. We simultaneously measured LFOs at the peripheral left earlobes (LE), right earlobes (RE), left fingertips (LF), right fingertips (RF), left toes (LT), and right toes (RT), along with coherence and phase shift analysis processing.ResultsThe coherence coefficients in the PAD group were lower than those in the healthy group ( p < .01), and the phase shifts in the PAD group were higher than those in the healthy group ( p < .01) in a resting state. Mild to moderate PAD patients had greater coherence coefficients and smaller phase shifts than severe PAD patients. 0.05 Hz PLR LFOs originating in the LT can be observed in other peripheral positions. The proportion of occurrence times for 0.05 Hz PLR LFOs peaks observed at different peripheral positions was different in healthy subjects, patients with bilateral multiple lower limb arteriosclerosis, and those with left or right lower limb arteriosclerosis.ConclusionThe coherence coefficient and phase shift characteristics of LFOs were different between healthy subjects and PAD patients. LFOs have the potential to provide valuable physiological process information associated with atherosclerosis in the periphery.

中文翻译：

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被动抬腿调节外周动脉粥样硬化的低频振荡传播：一项试点研究

目的在外周观察到的低频振荡（LFO）可能反映生理过程。本研究的目的是调查这些过程对 LFO 的影响以及健康受试者和周围动脉硬化疾病 (PAD) 患者之间的差异。方法对 14 名 PAD 患者和 25 名健康对照进行静息 (RS) 和被动抬腿 (PLR) 的研究。 ） 状态。我们同时测量了左耳垂 (LE)、右耳垂 (RE)、左指尖 (LF)、右指尖 (RF)、左脚趾 (LT) 和右脚趾 (RT) 的 LFO，以及相干性和相移结果静息状态下，PAD 组的相干系数低于健康组 ( p < .01)，且 PAD 组的相移高于健康组 ( p < .01)。状态。轻度至中度 PAD 患者比重度 PAD 患者具有更大的相干系数和更小的相移。在其他外围位置可以观察到源自 LT 的 0.05 Hz PLR LFO。健康人、双侧多发性下肢动脉硬化患者、左、右下肢动脉硬化患者在不同外周位置观察到的0.05 Hz PLR LFO峰值出现次数比例不同。结论LFO的相干系数和相移特性为健康受试者和 PAD 患者之间存在差异。 LFO 有潜力提供与外周动脉粥样硬化相关的有价值的生理过程信息。