The optimal analgesia regimen after open cardiac surgery is unclear. The aim of this study was to investigate the beneficial effects of continuous transversus thoracis muscle plane (TTMP) blocks initiated before surgery on open cardiac surgery outcomes. A group of 110 patients were randomly allocated to either receive bilateral continuous TTMP blocks (TTP group) or no nerve block (SAL group). The primary endpoint was post‐operative pain at 4, 8, 16, 24, 48 and 72 h after extubation at rest and exercise. The secondary outcome measures included analgesia requirements (sufentanil and flurbiprofen axetil administration), time to extubation, incidence of reintubation, length of stay in the ICU, incidence of post‐operative nausea and vomiting (PONV), time until return of bowel function, time to mobilization, urinary catheter removal and length of hospital stay. The length of stay in the ICU and length of hospital stay were significantly longer in the SAL group than in the TTP group. NRS scores at rest and exercise were significantly lower in the TTP group than in the SAL group at all time points. The TTP group required significantly less intraoperative and post‐operative sufentanil and post‐operative dynastat consumption than the SAL group. Time to extubation, time to first flatus, time until mobilization and time until urinary catheter removal were significantly earlier in the TTP group than in the SAL group. The incidence of PONV was significantly lower in the TTP group. Bilateral continuous TTMP blocks provide effective analgesia and accelerate recovery in patients undergoing open heart valve replacement surgery.

中文翻译：

---

连续胸横肌平面阻滞用于心脏瓣膜置换手术患者的随机临床试验

心脏直视手术后的最佳镇痛方案尚不清楚。本研究的目的是调查术前开始的连续胸横肌平面 (TTMP) 阻滞对心脏直视手术结果的有益影响。 110 名患者被随机分配接受双侧连续 TTMP 阻滞（TTP 组）或不接受神经阻滞（SAL 组）。主要终点是拔管后休息和运动时 4、8、16、24、48 和 72 小时的术后疼痛。次要结局指标包括镇痛需求（舒芬太尼和氟比洛芬酯给药）、拔管时间、再插管发生率、入住 ICU 的时间、术后恶心呕吐 (PONV) 发生率、肠功能恢复时间、时间活动、导尿管拔除和住院时间。 SAL组的ICU住院时间和住院时间明显长于TTP组。在所有时间点，TTP 组在休息和运动时的 NRS 评分均显着低于 SAL 组。 TTP 组术中和术后舒芬太尼和术后 dynastat 的消耗量显着低于 SAL 组。 TTP 组的拔管时间、首次排气时间、活动时间和拔除导尿管时间均显着早于 SAL 组。 TTP 组 PONV 的发生率明显较低。双侧连续 TTMP 阻滞可为接受心脏瓣膜置换手术的患者提供有效的镇痛并加速康复。