Extremity and truncal soft tissue sarcomas are a heterogeneous group of rare cancers that arise from mesenchymal tissues. Hence, the adoption of tailored risk assessment and prognostication tools plays a crucial role in optimizing the decision-making for which of the many possible treatment strategies to select. Management of these tumors requires a multidisciplinary strategy, which has seen significant development in recent decades. Surgery has emerged as the primary treatment approach, with the main goal of achieving microscopic negative tumor margins. To reduce the likelihood of local recurrence, loco-regional treatments such as radiation therapy and isolated limb perfusion are often added to the treatment regimen in combination with surgery. This approach also enables surgeons to perform limb-sparing surgery, particularly in cases where a positive tumor margin is expected. Chemotherapy may also provide a further benefit in decreasing the probability of local recurrence or reducing distant metastasis in selected patients. Selecting the optimal treatment strategy for these rare tumors is best accomplished by an experienced multi-disciplinary team.

中文翻译：

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四肢和躯干软组织肉瘤：风险评估和多学科管理

四肢和躯干软组织肉瘤是一组由间充质组织产生的异质性罕见癌症。因此，采用定制的风险评估和预测工具对于优化决策以选择多种可能的治疗策略至关重要。这些肿瘤的治疗需要多学科策略，近几十年来已经取得了显着的发展。手术已成为主要的治疗方法，其主要目标是实现显微镜下肿瘤边缘阴性。为了减少局部复发的可能性，局部区域治疗（例如放射治疗和孤立肢体灌注）通常与手术联合添加到治疗方案中。这种方法还使外科医生能够进行保肢手术，特别是在预计肿瘤边缘呈阳性的情况下。化疗还可以进一步降低选定患者局部复发的可能性或减少远处转移。为这些罕见肿瘤选择最佳治疗策略最好由经验丰富的多学科团队来完成。