Phosphatase and tensin homologue deleted on chromosome ten (PTEN) was initially recognized as a significant regulator of cancer suppression and could impede cancer cell survival, proliferation, and energy metabolism. PTEN is highly expressed in neurons and performs crucial functions in neurogenesis, synaptogenesis, and neuronal survival. Disruption of PTEN activity may also result in abnormal neuronal function and is associated with various neurological disorders, including stroke, seizures, and autism. Although several studies have shown that PTEN is involved in the development and degenerative processes of the nervous system, there is still a lack of in-depth studies that summarize and analyse patterns of cooperation between authors, institutions, countries, and journals, as well as research hotspots and trends in this important field. To identify and further visualize the cooperation and comprehend the development and trends of PTEN in the nervous system, especially in neural development and neurological diseases, we used a bibliometric analysis to identify relevant publications on this topic. We first found that the number of publications displayed a growing trend with time, but this was not stable. Universities, institutions, and authors from the United States are leading in this area of research. In addition, many cutting-edge research results have been discovered, such as key regulatory molecules and cellular mechanisms of PTEN in the nervous system, which may provide novel intervention targets and precise therapeutic strategies for related pathological injuries and diseases. Finally, the literature published within the last 5 years is discussed to identify future research trends regarding PTEN in the nervous system. Taken together, our findings, analysed using bibliometrics, may reflect research hotspots and trends, providing a reference for studying PTEN in the nervous system, especially in neural development and neurological diseases. These findings can assist new researchers in developing their research interests and gaining basic information. Moreover, our findings also may provide precise clinical guidelines and strategies for treating nervous system injuries and diseases caused by PTEN dysfunction.

中文翻译：

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PTEN 在神经发育和神经变性中的文献计量分析

十号染色体上缺失的磷酸酶和张力蛋白同源物 (PTEN) 最初被认为是癌症抑制的重要调节因子，可能阻碍癌细胞存活、增殖和能量代谢。 PTEN 在神经元中高度表达，在神经发生、突触发生和神经元存活中发挥重要作用。 PTEN 活性的破坏还可能导致神经元功能异常，并与各种神经系统疾病相关，包括中风、癫痫发作和自闭症。尽管多项研究表明PTEN参与神经系统的发育和退行性过程，但仍缺乏深入的研究来总结和分析作者、机构、国家和期刊之间的合作模式以及这一重要领域的研究热点和趋势。为了确定和进一步可视化合作并理解 PTEN 在神经系统中，特别是在神经发育和神经系统疾病中的发展和趋势，我们使用文献计量分析来确定有关该主题的相关出版物。我们首先发现出版物的数量随着时间的推移呈现出增长的趋势，但这并不稳定。美国的大学、机构和作者在这一研究领域处于领先地位。此外，还发现了许多前沿研究成果，如PTEN在神经系统中的关键调控分子和细胞机制，可能为相关病理损伤和疾病提供新的干预靶点和精准治疗策略。最后，讨论了过去 5 年内发表的文献，以确定神经系统中 PTEN 的未来研究趋势。综上所述，通过文献计量学分析，我们的研究结果可能反映了研究热点和趋势，为研究PTEN在神经系统，特别是神经发育和神经系统疾病中的作用提供了参考。这些发现可以帮助新研究人员发展他们的研究兴趣并获得基本信息。此外，我们的研究结果还可能为治疗 PTEN 功能障碍引起的神经系统损伤和疾病提供精确的临床指南和策略。