A total of five new mexicanolides (1–5), namely alliaxylines A–E, together with two known limonoids 6 and 7, were isolated and identified from Dysoxylum alliaceum (Blume) Blume ex. A.Juss. (Meliaceae). The structures of these compounds were elucidated based on extensive spectroscopic analyses, including HR-ESI–MS, UV, IR, 1D, and 2D NMR, as well as theoretical stimulation of NMR shifts with the DP4 + algorithm. Consequently, this study aimed to examine cytotoxic activities of these compounds against MCF-7 and A549 cell lines. The results implied that compound 2 was the most potent against the two tested cells, with IC₅₀ values of 34.95 ± 0.21 and 44.39 ± 1.03 µM.

Graphical Abstract

中文翻译：

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Alliaxylines A–E：来自 Dysoxylum alliaceum (Blume) Blume ex A.Juss 茎皮的五种新墨西哥内酯

从Dysoxylum alliaceum (Blume) Blume ex.中分离并鉴定出总共五种新的 mexicanolides ( 1 – 5 )，即 alliaxylines A–E，以及两种已知的柠檬苦素6和7 。 A.朱斯. （楝科）。这些化合物的结构是基于广泛的光谱分析（包括 HR-ESI-MS、UV、IR、1D 和 2D NMR）以及使用 DP4 + 算法对 NMR 位移的理论模拟来阐明的。因此，本研究旨在检查这些化合物对 MCF-7 和 A549 细胞系的细胞毒活性。结果表明，化合物2对两种测试细胞最有效，IC ₅₀值为 34.95 ± 0.21 和 44.39 ± 1.03 µM。

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