Abstract

Hydrolysis reactions are capable of directing the non-equilibrium assembly of biomolecular scaffolds to realize sophisticated structures and functions in natural systems. However, utilizing the proper hydrolysis reactions to construct controlled assemblies with complex topologies is still an arduous challenge in artificial systems and needs to be addressed. Herein, we report a nitric oxide (NO)-triggered slow hydrolysis strategy for the controlled construction of biomimetic supramolecular toroids (STs), thus realizing their visualization of intermediate structures and regulation of geometry parameters. This presented protocol harnesses hydrolysis reactions to control of non-equilibrium self-assembly processes for the construction of self-assemblies with complex topologies successfully, which sheds light on how the hydrolysis reaction rate can modulate the kinetic pathway of assembly, thus realizing the artificial establishment of bio-inspired hierarchical structures.

中文翻译：

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一氧化氮触发的水解反应构建具有复杂拓扑的受控自组装体

摘要

水解反应能够引导生物分子支架的非平衡组装，以实现自然系统中复杂的结构和功能。然而，利用适当的水解反应构建具有复杂拓扑的受控组件仍然是人工系统中的艰巨挑战，需要解决。在此，我们报告了一种一氧化氮（NO）触发的缓慢水解策略，用于仿生超分子环形（ST）的受控构建，从而实现中间结构的可视化和几何参数的调节。该方案利用水解反应来控制非平衡自组装过程，成功构建了具有复杂拓扑的自组装体，揭示了水解反应速率如何调节组装的动力学途径，从而实现了人工建立受生物启发的层次结构。