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Cryptococcus neoformans rapidly invades the murine brain by sequential breaching of airway and endothelial tissues barriers, followed by engulfment by microglia
mBio ( IF 6.4 ) Pub Date : 2024-03-21 , DOI: 10.1128/mbio.03078-23
Vanessa I. Francis 1, 2 , Corin Liddle 3 , Emma Camacho 4 , Madhura Kulkarni 4 , Samuel R. S. Junior 4 , Jamie A. Harvey 1 , Elizabeth R. Ballou 1 , Darren D. Thomson 1 , Gordon D. Brown 1, 2 , J. Marie Hardwick 4 , Arturo Casadevall 4 , Jonathan Witton 2 , Carolina Coelho 1, 2
Affiliation  

Cryptococcal meningitis causes 10%–15% of AIDS-associated deaths globally. Still, brain-specific immunity to cryptococci is a conundrum. By employing innovative imaging, this study reveals what occurs during the first days of infection in brain and in ...

中文翻译:

新型隐球菌通过连续突破气道和内皮组织屏障,迅速侵入小鼠大脑,随后被小胶质细胞吞噬

全球 10%–15% 的艾滋病相关死亡由隐球菌性脑膜炎引起。尽管如此,大脑对隐球菌的特异性免疫仍然是一个难题。通过采用创新的成像技术,这项研究揭示了大脑和体内感染的第一天发生的情况。
更新日期:2024-03-22
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