Task-free brain activity exhibits spontaneous fluctuations between functional states, characterized by synchronized activation patterns in distributed resting-state (RS) brain networks. The temporal dynamics of the networks’ electrophysiological signatures reflect individual variations in brain activity and connectivity linked to mental states and cognitive functions and can predict or monitor vulnerability to develop psychiatric or neurological disorders. In particular, RS alpha fluctuations modulate perceptual sensitivity, attentional shifts, and cognitive control, and could therefore reflect a neural correlate of increased vulnerability to sensory distortions, including the proneness to hallucinatory experiences. We recorded 5 min of RS EEG from 33 non-clinical individuals varying in hallucination proneness (HP) to investigate links between task-free alpha dynamics and vulnerability to hallucinations. To this end, we used a dynamic brain state allocation method to identify five recurrent alpha states together with their spatiotemporal dynamics and most active brain areas through source reconstruction. The dynamical features of a state marked by activation in somatosensory, auditory, and posterior default-mode network areas predicted auditory and auditory-verbal HP, but not general HP, such that individuals with higher vulnerability to auditory hallucinations spent more time in this state. The temporal dynamics of spontaneous alpha activity might reflect individual differences in attention to internally generated sensory events and altered auditory perceptual sensitivity. Altered RS alpha dynamics could therefore instantiate a neural marker of increased vulnerability to auditory hallucinations.

无任务的大脑活动表现出功能状态之间的自发波动，其特征是分布式静息态（RS）大脑网络中的同步激活模式。网络电生理特征的时间动态反映了与精神状态和认知功能相关的大脑活动和连接性的个体差异，并且可以预测或监测发生精神或神经系统疾病的脆弱性。特别是，RS α波动调节知觉敏感性、注意力转移和认知控制，因此可以反映与感觉扭曲（包括幻觉体验倾向）的脆弱性增加有关的神经相关性。我们记录了 33 名不同幻觉倾向 (HP) 的非临床个体的 5 分钟 RS 脑电图，以研究无任务 α 动态与幻觉脆弱性之间的联系。为此，我们使用动态大脑状态分配方法通过源重建来识别五个经常出现的阿尔法状态及其时空动态和最活跃的大脑区域。以体感、听觉和后部默认模式网络区域激活为标志的状态的动态特征预测听觉和听觉言语 HP，但不能预测一般 HP，因此更易受幻听影响的个体会在这种状态下花费更多时间。自发阿尔法活动的时间动态可能反映了对内部产生的感觉事件的关注和改变的听觉感知敏感性的个体差异。因此，改变的 RS α 动力学可以实例化一个神经标记，表明对幻听的脆弱性增加。