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Clinical implications of airway obstruction with normal or low FEV1 in childhood and adolescence
Thorax ( IF 10 ) Pub Date : 2024-03-21 , DOI: 10.1136/thorax-2023-220952
Hans Jacob Lohne Koefoed , Gang Wang , Ulrike Gehring , Sandra Ekstrom , Inger Kull , Roel Vermeulen , Jolanda M A Boer , Anna Bergstrom , Gerard H Koppelman , Erik Melén , Judith M Vonk , Jenny Hallberg

Background Airway obstruction is defined by spirometry as a low forced expiratory volume in 1 s (FEV1) to forced vital capacity (FVC) ratio. This impaired ratio may originate from a low FEV1 (classic) or a normal FEV1 in combination with a large FVC (dysanaptic). The clinical implications of dysanaptic obstruction during childhood and adolescence in the general population remain unclear. Aims To investigate the association between airway obstruction with a low or normal FEV1 in childhood and adolescence, and asthma, wheezing and bronchial hyperresponsiveness (BHR). Methods In the BAMSE (Barn/Child, Allergy, Milieu, Stockholm, Epidemiology; Sweden) and PIAMA (Prevention and Incidence of Asthma and Mite Allergy; the Netherlands) birth cohorts, obstruction (FEV1:FVC ratio less than the lower limit of normal, LLN) at ages 8, 12 (PIAMA only) or 16 years was classified as classic (FEV1

中文翻译:

儿童和青少年时期 FEV1 正常或较低的气道阻塞的临床意义

背景 气道阻塞通过肺活量测定法定义为 1 秒用力呼气量 (FEV1) 与用力肺活量 (FVC) 之比较低。该比率受损可能源自较低的 FEV1(经典)或正常的 FEV1 与较大的 FVC(呼吸功能障碍)。在一般人群中,儿童期和青春期的接触不良阻塞的临床意义仍不清楚。目的 调查儿童期和青少年期 FEV1 较低或正常的气道阻塞与哮喘、喘息和支气管高反应性 (BHR) 之间的关联。方法 在 BAMSE(Barn/Child、Allergy、Milieu、Stockholm、Epidemiology;瑞典)和 PIAMA(Prevention and Incidence of Asthma and Mite Allergy;荷兰)出生队列中,阻塞(FEV1:FVC 比值低于正常下限) ,LLN)在 8 岁、12 岁(仅限 PIAMA)或 16 岁时被归类为经典(FEV1
更新日期:2024-03-22
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