Background The rPAP respiratory support system, used for delivery room stabilisation with nasal prongs, has been shown to reduce the need for intubation in extremely preterm infants. A simplified version of the system has been developed. The purpose of this study was to determine the feasibility of providing uninterrupted respiratory support with the simplified rPAP from birth up to 4 hours of life and to assess ease of use for skin-to skin stabilisation. Methods This was a non-randomised feasibility study conducted at Karolinska University Hospital, Sweden. Respiratory support with continuous positive airway pressure (CPAP) and positive pressure ventilation if needed was given with the simplified rPAP using heated humidified gases. Respiratory support was provided in the delivery room, during transportation and in the neonatal unit, for a maximum of 4 hours. Results 32 preterm infants with a mean (SD) gestational age of 33.4 weeks (±1.2) were included. Of 17 infants born vaginally, 13 were stabilised skin-to-skin. The remaining infants were stabilised on a resuscitation table. All infants received CPAP and nine received positive pressure ventilation. 31 infants received continued support during transport and after arrival in the neonatal unit. Minor interruptions in CPAP support occurred in all infants. The study did not reveal problems with usability of the system. Conclusion It is feasible to stabilise preterm infants with the simplified respiratory support system both skin-to-skin and on a resuscitation table, and to provide continued respiratory support with the same system during transportation and in the neonatal unit. Trial registration number [NCT04244890][1]. Data are available upon reasonable request. [1]: /lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT04244890&atom=%2Ffetalneonatal%2Fearly%2F2024%2F03%2F25%2Farchdischild-2023-326409.atom

中文翻译：

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早产儿出生后皮肤接触稳定和不间断呼吸支持：新型简化 rPAP 系统的可行性

背景 rPAP 呼吸支持系统用于通过鼻塞稳定产房，已被证明可以减少极早产儿插管的需要。该系统的简化版本已经开发出来。本研究的目的是确定使用简化的 rPAP 从出生到出生后 4 小时提供不间断呼吸支持的可行性，并评估皮肤与皮肤稳定的易用性。方法 这是在瑞典卡罗林斯卡大学医院进行的一项非随机可行性研究。通过使用加热加湿气体的简化 rPAP 提供持续气道正压通气 (CPAP) 和正压通气（如果需要）的呼吸支持。在产房、转运期间和新生儿病房提供呼吸支持，时间最长为 4 小时。结果 纳入 32 名平均 (SD) 胎龄为 33.4 周 (±1.2) 的早产儿。 17 名顺产婴儿中，有 13 名皮肤接触情况稳定。其余婴儿在复苏床上稳定下来。所有婴儿均接受 CPAP 治疗，其中 9 名婴儿接受正压通气。 31 名婴儿在转运期间和抵达新生儿病房后得到持续支持。所有婴儿的 CPAP 支持均出现轻微中断。该研究没有揭示系统可用性的问题。结论 通过皮肤接触和复苏台上的简化呼吸支持系统稳定早产儿的情况是可行的，并且在转运期间和新生儿病房中使用同一系统提供持续的呼吸支持是可行的。试用注册号[NCT04244890][1]。数据可根据合理要求提供。 [1]: /lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT04244890&atom=%2Ffetalneonatal%2Fearly%2F2024%2F03%2F25%2Farchdischild-2023-326409.atom