In this study, two new kaurane diterpenes (16, 17), together with 12 lignans (1–12), a triterpene (15), and two other compounds (13, 14) were isolated from the woods of Agathis dammara. The structure of the new compound was determined by HR ESIMS and 1D/2D NMR spectroscopy, and its absolute configuration was determined by electronic circular dichroism (ECD) exciton chirality method. Compounds 5, 11, 14 exhibit significant hypoglycaemic activity in zebrafish, and their mechanism of action is to enhance glucose uptake in zebrafish.

Graphical Abstract

中文翻译：

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来自达玛拉的化合物通过增强葡萄糖摄取发挥降血糖活性：木脂素、萜烯等

在这项研究中，从Agathis dammara的树林中分离出了两种新的贝壳杉烷二萜 (1 6 , 17 ) 以及 12 种木脂素 ( 1-12 )、一种三萜 ( 15 ) 和其他两种化合物 ( 13 , 14 ) 。通过HR ESIMS和1D/2D NMR光谱确定了新化合物的结构，并通过电子圆二色性（ECD）激子手性方法确定了其绝对构型。化合物5、11、14在斑马鱼中表现出显着的降血糖活性，其作用机制是增强斑马鱼的葡萄糖摄取。

图形概要