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Mitotic bookmarking by transcription factors: be aware of redundancy
Trends in Biochemical Sciences ( IF 13.8 ) Pub Date : 2024-03-18 , DOI: 10.1016/j.tibs.2024.03.003
Miguel V. Silva , Diogo S. Castro

A recent report by shows redundant functions for the transcription factors (TFs) ESRRB and NR5A2 as mitotic bookmarkers in mouse embryonic stem (ES) cells. These occupy some of their target sites in mitotic chromatin, ensuring their robust reactivation after cell division, including markers and regulators of pluripotency.

中文翻译:

转录因子的有丝分裂书签:注意冗余

最近的一份报告显示转录因子 (TF) ESRRB 和 NR5A2 作为小鼠胚胎干 (ES) 细胞中有丝分裂书签的冗余功能。它们占据有丝分裂染色质中的一些靶位点,确保它们在细胞分裂后强劲地重新激活,包括多能性的标记和调节因子。
更新日期:2024-03-18
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