Despite altered brain activities being associated with suicidal ideation (SI), the neural correlates of SI in major depressive disorder (MDD) have remained elusive. We enrolled 82 first‐episode drug‐naïve MDD patients including 41 with SI and 41 without SI, as well as 41 healthy controls (HCs). Resting‐state functional and structural MRI data were collected. The measures of fractional amplitude of low‐frequency fluctuation (fALFF) and grey matter volume (GMV) were calculated and compared. Compared with HCs, patients with SI exhibited increased fALFF values in the right rectus gyrus and left medial superior frontal gyrus, middle frontal gyrus and precuneus. Decreased GMV in the right parahippocampal gyrus, insula and middle occipital gyrus and increased GMV in the left superior frontal gyrus were detected in patients with SI. In addition, patients without SI demonstrated increased fALFF values in the right superior frontal gyrus and decreased fALFF values in the right postcentral gyrus. Decreased GMV in the left superior frontal gyrus, right medial superior frontal gyrus, opercular part of inferior frontal gyrus, postcentral gyrus, fusiform gyrus and increased left supplementary motor area, superior occipital gyrus, right anterior cingulate gyrus and superior temporal gyrus were revealed in patients with SI. Moreover, in comparison with patients without SI, increased fALFF values were identified in the left precuneus of patients with SI. However, no significant differences were found in GMV between patients with and without SI. These findings might be helpful for finding neuroimaging markers predicting individual suicide risk and detecting targeted brain regions for effective early interventions.

中文翻译：

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有和没有自杀意念的首发药物重度抑郁症患者静息态大脑活动的差异

尽管大脑活动的改变与自杀意念（SI）有关，但重度抑郁症（MDD）中 SI 的神经相关性仍然难以捉摸。我们招募了 82 名初次用药 MDD 患者，其中 41 名患有 SI，41 名没有 SI，以及 41 名健康对照 (HC)。收集静息态功能和结构 MRI 数据。计算并比较了低频波动分数幅度（fALFF）和灰质体积（GMV）的测量值。与HCs相比，SI患者的右侧直肌回、左侧内侧额上回、额中回和楔前叶的fALFF值升高。 SI患者的右侧海马旁回、岛叶和枕中回GMV降低，左侧额上回GMV升高。此外，没有 SI 的患者表现出右侧额上回的 fALFF 值增加和右侧中央后回的 fALFF 值降低。患者发现左侧额上回、右侧额上回内侧、额下回盖部、中央后回、梭状回GMV降低，左侧辅助运动区、枕上回、右侧扣带回和颞上回增加与 SI。此外，与没有 SI 的患者相比，SI 患者左侧楔前叶的 fALFF 值增加。然而，患有和不患有SI的患者之间的GMV没有发现显着差异。这些发现可能有助于寻找预测个体自杀风险的神经影像标记，并检测目标大脑区域以进行有效的早期干预。