Polyether ether ketone (PEEK) is gaining recognition as a highly promising polymer for orthopedic implants, attributed to its exceptional biocompatibility, ease of processing, and radiation resistance. However, its long‐term in vivo application faces challenges, primarily due to suboptimal osseointegration from postimplantation inflammation and immune reactions. Consequently, biofunctionalization of PEEK implant surfaces emerges as a strategic approach to enhance osseointegration and increase the overall success rates of these implants. In our research, we engineered a multifaceted PEEK implant through the in situ integration of chitosan‐coated zinc‐doped bioactive glass nanoparticles (Zn‐BGNs). This novel fabrication imbues the implant with immunomodulatory capabilities while bolstering its osseointegration potential. The biofunctionalized PEEK composite elicited several advantageous responses; it facilitated M2 macrophage polarization, curtailed the production of inflammatory mediators, and augmented the osteogenic differentiation of bone marrow mesenchymal stem cells. The experimental findings underscore the vital and intricate role of biofunctionalized PEEK implants in preserving normal bone immunity and metabolism. This study posits that utilizing chitosan‐BGNs represents a direct and effective method for creating multifunctional implants. These implants are designed to facilitate biomineralization and immunomodulation, making them especially apt for orthopedic applications.

中文翻译：

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掺锌生物活性玻璃功能化聚醚醚酮增强骨再生的生物反应

聚醚醚酮 (PEEK) 因其卓越的生物相容性、易于加工和耐辐射性而被认为是一种非常有前途的骨科植入物聚合物。然而，其在体内的长期应用面临挑战，主要是由于植入后炎症和免疫反应导致骨整合不理想。因此，PEEK 种植体表面的生物功能化成为增强骨整合并提高这些种植体总体成功率的战略方法。在我们的研究中，我们通过原位整合壳聚糖涂层的掺锌生物活性玻璃纳米粒子（Zn-BGN）设计了多面 PEEK 植入物。这种新颖的制造方法使植入物具有免疫调节能力，同时增强其骨整合潜力。生物功能化 PEEK 复合材料引发了多种有利的反应；它促进 M2 巨噬细胞极化，减少炎症介质的产生，并增强骨髓间充质干细胞的成骨分化。实验结果强调了生物功能化 PEEK 植入物在维持正常骨免疫和代谢方面的重要而复杂的作用。这项研究认为，利用壳聚糖-BGN 是制造多功能植入物的直接有效的方法。这些植入物旨在促进生物矿化和免疫调节，使其特别适合骨科应用。