Chemokine receptors are members of the G protein-coupled receptor superfamily. The C-X-C chemokine receptor type 4 (CXCR4), one of the most studied chemokine receptors, is widely expressed in hematopoietic and immune cell populations. It is involved in leukocyte trafficking in lymphoid organs and inflammatory sites through its interaction with its natural ligand CXCL12. CXCR4 assumes a pivotal role in B-cell development, ranging from early progenitors to the differentiation of antibody-secreting cells. This review emphasizes the significance of CXCR4 across the various stages of B-cell development, including central tolerance, and delves into the association between CXCR4 and B cell-mediated disorders, from immunodeficiencies such as WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome to autoimmune diseases such as systemic lupus erythematosus. The potential of CXCR4 as a therapeutic target is discussed, especially through the identification of novel molecules capable of modulating specific pockets of the CXCR4 molecule. These insights provide a basis for innovative therapeutic approaches in the field.

中文翻译：

---

CXCR4：从 B 细胞发育到 B 细胞介导的疾病。

趋化因子受体是 G 蛋白偶联受体超家族的成员。 CXC 趋化因子受体 4 型 (CXCR4) 是研究最多的趋化因子受体之一，广泛表达于造血细胞和免疫细胞群中。它通过与其天然配体 CXCL12 相互作用参与淋巴器官和炎症部位的白细胞运输。 CXCR4 在 B 细胞发育中发挥着关键作用，从早期祖细胞到抗体分泌细胞的分化。本综述强调了 CXCR4 在 B 细胞发育各个阶段（包括中枢耐受性）中的重要性，并深入研究了 CXCR4 与 B 细胞介导的疾病（例如 WHIM（疣、低丙种球蛋白血症、感染和骨髓缺乏症）等免疫缺陷）之间的关联自身免疫性疾病综合征，如系统性红斑狼疮。讨论了 CXCR4 作为治疗靶点的潜力，特别是通过鉴定能够调节 CXCR4 分子特定口袋的新分子。这些见解为该领域的创新治疗方法奠定了基础。