Introduction Achieving viral load suppression is crucial for the prevention of complications and deaths related to HIV infection. Ethiopia has embraced the worldwide 95-95-95 target, but there is no national representative information regarding virological suppression. Therefore, this review aims to determine the pooled virological suppression rate and identify the pooled effect of contributing factors of viral suppression for HIV-positive patients on antiretroviral therapy in Ethiopia. Method We systematically searched websites and databases, including online repositories, to obtain primary studies. We assessed the quality of the included articles using the Newcastle‒Ottawa Scale appraisal checklist by two reviewers. Publication bias was checked using Egger’s regression test, the heterogeneity of the studies was assessed using Iʌ2 statistics and Q statistics, and sensitivity analysis was performed to identify any outlier results in the included studies. The Der Simonian Laird random-effects model was used to estimate the overall proportion of viral suppression, and STATA 17 statistical software was used for all types of analysis. Result A total of 21 eligible articles primarily conducted in Ethiopia using HIV program data were used for this quantitative synthesis. The overall pooled virological suppression was 71% (95% CI: 64%, 77%). The pooled effects of poor adherence to ART [(AOR:0.33, 95% CI: 0.28, 0.40)], body mass index (18.5-24.9 kg/m2) [(AOR:1.8, 95% CI: 1.37, 2.36)], disclosure [(AOR:1.41, 95% CI: 1.05, 1.89)], absence of opportunistic infection [(AOR:1.68, 95% CI: 1.43, 1.97)], and high baseline viral load count [(AOR:0.65, 95% CI: 0.52, 0.81)] were identified as significant predictors of viral suppression. Conclusion The overall pooled percentage of virological suppression was low compared with the global target of viral suppression and the Ethiopian public health institute report. Poor adherence, normal body mass index, disclosure, absence of opportunistic infection and high baseline viral load count were contributing factors of viral suppression in Ethiopia. Responsible stakeholders should maximize their effort to achieve the global target of virological suppression by addressing significant predictors.

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埃塞俄比亚接受抗逆转录病毒治疗的艾滋病毒/艾滋病患者的病毒学抑制及其预测因素：系统评价和荟萃分析

简介 实现病毒载量抑制对于预防与 HIV 感染相关的并发症和死亡至关重要。埃塞俄比亚已实现全球 95-95-95 目标，但没有关于病毒抑制的国家代表性信息。因此，本综述旨在确定埃塞俄比亚艾滋病病毒阳性患者病毒抑制的汇总病毒抑制因素对抗逆转录病毒治疗的汇总影响。方法 我们系统地搜索网站和数据库，包括在线存储库，以获得初步研究。我们使用两位审稿人的纽卡斯尔-渥太华量表评估清单评估了纳入文章的质量。使用 Egger 回归检验检查发表偏倚，使用 Iʌ2 统计和 Q 统计评估研究的异质性，并进行敏感性分析以识别纳入研究中的任何异常结果。 Der Simonian Laird 随机效应模型用于估计病毒抑制的总体比例，STATA 17 统计软件用于所有类型的分析。结果 总共 21 篇主要在埃塞俄比亚使用 HIV 项目数据进行的合格文章被用于本次定量综合。总体汇总病毒学抑制率为 71%（95% CI：64%、77%）。 ART 依从性差 [(AOR:0.33, 95% CI: 0.28, 0.40)]、体重指数 (18.5-24.9 kg/m2) [(AOR:1.8, 95% CI: 1.37, 2.36)] 的综合影响、披露 [(AOR:1.41, 95% CI: 1.05, 1.89)]、不存在机会性感染 [(AOR:1.68, 95% CI: 1.43, 1.97)] 和高基线病毒载量计数 [(AOR:0.65, 95% CI: 0.52, 0.81)] 被确定为病毒抑制的重要预测因子。结论 与全球病毒抑制目标和埃塞俄比亚公共卫生研究所的报告相比，病毒学抑制的总体汇总百分比较低。依从性差、体重指数正常、信息披露、没有机会性感染和高基线病毒载量是埃塞俄比亚病毒抑制的因素。负责任的利益攸关方应通过解决重要的预测因素，尽最大努力实现病毒学抑制的全球目标。